Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation

Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer...

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Detalles Bibliográficos
Autores principales: Wang, Peng, Yuan, Hui-Hui, Zhang, Xue, Li, Yun-Ping, Shang, Lu-Qing, Yin, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271160/
https://www.ncbi.nlm.nih.gov/pubmed/24566315
http://dx.doi.org/10.3390/molecules19022469
Descripción
Sumario:Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed.

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