A Novel Synthesis of the Oxazolidinone Antithrombotic Agent Rivaroxaban

A facile synthetic route of rivaroxaban has been developed. Using commercially available (R)-epichlorohydrin and bromobenzene as the starting materials, rivaroxaban was obtained in 39% overall yield using a Goldberg coupling as the key step. The synthetic route represents a convenient procedure for...

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Detalles Bibliográficos
Autores principales: Yuan, Jianyong, Liu, Kai, Li, Lun, Yuan, Yong, Liu, Xuelei, Li, Yanwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271174/
https://www.ncbi.nlm.nih.gov/pubmed/25237754
http://dx.doi.org/10.3390/molecules190914999
Descripción
Sumario:A facile synthetic route of rivaroxaban has been developed. Using commercially available (R)-epichlorohydrin and bromobenzene as the starting materials, rivaroxaban was obtained in 39% overall yield using a Goldberg coupling as the key step. The synthetic route represents a convenient procedure for the production of rivaroxaban.

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