A Novel Synthesis of the Oxazolidinone Antithrombotic Agent Rivaroxaban

A facile synthetic route of rivaroxaban has been developed. Using commercially available (R)-epichlorohydrin and bromobenzene as the starting materials, rivaroxaban was obtained in 39% overall yield using a Goldberg coupling as the key step. The synthetic route represents a convenient procedure for...

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Detalles Bibliográficos
Autores principales: Yuan, Jianyong, Liu, Kai, Li, Lun, Yuan, Yong, Liu, Xuelei, Li, Yanwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271174/
https://www.ncbi.nlm.nih.gov/pubmed/25237754
http://dx.doi.org/10.3390/molecules190914999
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author Yuan, Jianyong
Liu, Kai
Li, Lun
Yuan, Yong
Liu, Xuelei
Li, Yanwu
author_facet Yuan, Jianyong
Liu, Kai
Li, Lun
Yuan, Yong
Liu, Xuelei
Li, Yanwu
author_sort Yuan, Jianyong
collection PubMed
description A facile synthetic route of rivaroxaban has been developed. Using commercially available (R)-epichlorohydrin and bromobenzene as the starting materials, rivaroxaban was obtained in 39% overall yield using a Goldberg coupling as the key step. The synthetic route represents a convenient procedure for the production of rivaroxaban.
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spelling pubmed-62711742018-12-27 A Novel Synthesis of the Oxazolidinone Antithrombotic Agent Rivaroxaban Yuan, Jianyong Liu, Kai Li, Lun Yuan, Yong Liu, Xuelei Li, Yanwu Molecules Communication A facile synthetic route of rivaroxaban has been developed. Using commercially available (R)-epichlorohydrin and bromobenzene as the starting materials, rivaroxaban was obtained in 39% overall yield using a Goldberg coupling as the key step. The synthetic route represents a convenient procedure for the production of rivaroxaban. MDPI 2014-09-18 /pmc/articles/PMC6271174/ /pubmed/25237754 http://dx.doi.org/10.3390/molecules190914999 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Yuan, Jianyong
Liu, Kai
Li, Lun
Yuan, Yong
Liu, Xuelei
Li, Yanwu
A Novel Synthesis of the Oxazolidinone Antithrombotic Agent Rivaroxaban
title A Novel Synthesis of the Oxazolidinone Antithrombotic Agent Rivaroxaban
title_full A Novel Synthesis of the Oxazolidinone Antithrombotic Agent Rivaroxaban
title_fullStr A Novel Synthesis of the Oxazolidinone Antithrombotic Agent Rivaroxaban
title_full_unstemmed A Novel Synthesis of the Oxazolidinone Antithrombotic Agent Rivaroxaban
title_short A Novel Synthesis of the Oxazolidinone Antithrombotic Agent Rivaroxaban
title_sort novel synthesis of the oxazolidinone antithrombotic agent rivaroxaban
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271174/
https://www.ncbi.nlm.nih.gov/pubmed/25237754
http://dx.doi.org/10.3390/molecules190914999
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