Palladium-Catalyzed Direct Addition of 2-Aminobenzonitriles to Sodium Arylsulfinates: Synthesis of o-Aminobenzophenones

The first example of the palladium-catalyzed synthesis of o-aminobenzophenones in moderate to excellent yields via a direct addition of sodium arylsulfinates to unprotected 2-aminobenzonitriles was reported. A plausible mechanism for the formation of o-aminobenzophenones involving desulfination and...

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Autores principales: Chen, Jiuxi, Li, Jianjun, Su, Weike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271184/
https://www.ncbi.nlm.nih.gov/pubmed/24853617
http://dx.doi.org/10.3390/molecules19056439
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author Chen, Jiuxi
Li, Jianjun
Su, Weike
author_facet Chen, Jiuxi
Li, Jianjun
Su, Weike
author_sort Chen, Jiuxi
collection PubMed
description The first example of the palladium-catalyzed synthesis of o-aminobenzophenones in moderate to excellent yields via a direct addition of sodium arylsulfinates to unprotected 2-aminobenzonitriles was reported. A plausible mechanism for the formation of o-aminobenzophenones involving desulfination and addition reactions was proposed. The utility of this transformation was demonstrated by its compatibility with a wide range of functional groups. Thus, the method represents a convenient and practical strategy for synthesis of o-aminobenzophenones.
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spelling pubmed-62711842018-12-21 Palladium-Catalyzed Direct Addition of 2-Aminobenzonitriles to Sodium Arylsulfinates: Synthesis of o-Aminobenzophenones Chen, Jiuxi Li, Jianjun Su, Weike Molecules Article The first example of the palladium-catalyzed synthesis of o-aminobenzophenones in moderate to excellent yields via a direct addition of sodium arylsulfinates to unprotected 2-aminobenzonitriles was reported. A plausible mechanism for the formation of o-aminobenzophenones involving desulfination and addition reactions was proposed. The utility of this transformation was demonstrated by its compatibility with a wide range of functional groups. Thus, the method represents a convenient and practical strategy for synthesis of o-aminobenzophenones. MDPI 2014-05-20 /pmc/articles/PMC6271184/ /pubmed/24853617 http://dx.doi.org/10.3390/molecules19056439 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chen, Jiuxi
Li, Jianjun
Su, Weike
Palladium-Catalyzed Direct Addition of 2-Aminobenzonitriles to Sodium Arylsulfinates: Synthesis of o-Aminobenzophenones
title Palladium-Catalyzed Direct Addition of 2-Aminobenzonitriles to Sodium Arylsulfinates: Synthesis of o-Aminobenzophenones
title_full Palladium-Catalyzed Direct Addition of 2-Aminobenzonitriles to Sodium Arylsulfinates: Synthesis of o-Aminobenzophenones
title_fullStr Palladium-Catalyzed Direct Addition of 2-Aminobenzonitriles to Sodium Arylsulfinates: Synthesis of o-Aminobenzophenones
title_full_unstemmed Palladium-Catalyzed Direct Addition of 2-Aminobenzonitriles to Sodium Arylsulfinates: Synthesis of o-Aminobenzophenones
title_short Palladium-Catalyzed Direct Addition of 2-Aminobenzonitriles to Sodium Arylsulfinates: Synthesis of o-Aminobenzophenones
title_sort palladium-catalyzed direct addition of 2-aminobenzonitriles to sodium arylsulfinates: synthesis of o-aminobenzophenones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271184/
https://www.ncbi.nlm.nih.gov/pubmed/24853617
http://dx.doi.org/10.3390/molecules19056439
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AT lijianjun palladiumcatalyzeddirectadditionof2aminobenzonitrilestosodiumarylsulfinatessynthesisofoaminobenzophenones
AT suweike palladiumcatalyzeddirectadditionof2aminobenzonitrilestosodiumarylsulfinatessynthesisofoaminobenzophenones

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