Cargando…
Correlation between Inflammatory Markers of Atherosclerosis and Carotid Intima-Media Thickness in Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA) is a sleep-related breathing disorder associated with the development of cardiovascular diseases and atherosclerosis. Systemic inflammation plays an important role in the development of cardiovascular complications in OSA patients. The aim of the study was to evaluate t...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271201/ https://www.ncbi.nlm.nih.gov/pubmed/24481114 http://dx.doi.org/10.3390/molecules19021651 |
_version_ | 1783376873696264192 |
---|---|
author | Ciccone, Marco Matteo Scicchitano, Pietro Zito, Annapaola Cortese, Francesca Boninfante, Barbara Falcone, Vito Antonio Quaranta, Vitaliano Nicola Ventura, Valentina Anna Zucano, Antonietta Di Serio, Francesca Damiani, Mario Francesco Resta, Onofrio |
author_facet | Ciccone, Marco Matteo Scicchitano, Pietro Zito, Annapaola Cortese, Francesca Boninfante, Barbara Falcone, Vito Antonio Quaranta, Vitaliano Nicola Ventura, Valentina Anna Zucano, Antonietta Di Serio, Francesca Damiani, Mario Francesco Resta, Onofrio |
author_sort | Ciccone, Marco Matteo |
collection | PubMed |
description | Obstructive Sleep Apnea (OSA) is a sleep-related breathing disorder associated with the development of cardiovascular diseases and atherosclerosis. Systemic inflammation plays an important role in the development of cardiovascular complications in OSA patients. The aim of the study was to evaluate the relationship between carotid intima-media thickness (cIMT) and inflammatory markers plasma levels in OSA patients. We enrolled 80 OSA patients and 40 controls matched for age and body mass index (BMI). The presence and severity of sleep apnea was determined by in-laboratory portable monitoring (PM). Demographic data, blood pressure, heart rate, and cIMT were measured. High-sensitive C-Reactive Protein (hsCRP), interleukin (IL)-6, tumor necrosis factor (TNF)-α and pentraxin (PTX)-3 serum concentrations were detected. cIMT was higher in OSA patients than controls (0.89 ± 0.13 mm vs. 0.65 ± 0.1 mm, p < 0.01). Moderate-severe OSA patients (0.95 ± 0.09 mm) had significantly increased cIMT than mild OSA (0.76 ± 0.1 mm; p < 0.01) and control (0.65 ± 0.1 mm; p < 0.01). hsCRP, IL-6, TNF-α, and PTX-3 in patients with OSA (1.67 ± 0.66 mg/L, 2.86 ± 1.39 pg/mL, 20.09 ± 5.39 pg/mL, 2.1 ± 0.59 ng/mL, respectively) were significantly higher than in controls (1.08 ± 0.53 mg/L, p < 0.01; 1.5 ± 0.67 pg/mL, p < 0.01; 12.53 ± 3.48 pg/mL, p < 0.01; 1.45 ± 0.41 ng/mL, p < 0.01, respectively). Carotid IMT was significantly correlated to CRP (r = 0.44; p < 0.01), IL-6 (r = 0.42; p < 0.01), TNF-α (r = 0.53; p < 0.01), and PTX-3 (r = 0.49; p < 0.01). OSA patients showed increased cIMT, CRP, IL-6, TNF-α, and PTX-3 levels. Inflammatory markers levels are correlated to cIMT in OSA patients. |
format | Online Article Text |
id | pubmed-6271201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62712012018-12-20 Correlation between Inflammatory Markers of Atherosclerosis and Carotid Intima-Media Thickness in Obstructive Sleep Apnea Ciccone, Marco Matteo Scicchitano, Pietro Zito, Annapaola Cortese, Francesca Boninfante, Barbara Falcone, Vito Antonio Quaranta, Vitaliano Nicola Ventura, Valentina Anna Zucano, Antonietta Di Serio, Francesca Damiani, Mario Francesco Resta, Onofrio Molecules Article Obstructive Sleep Apnea (OSA) is a sleep-related breathing disorder associated with the development of cardiovascular diseases and atherosclerosis. Systemic inflammation plays an important role in the development of cardiovascular complications in OSA patients. The aim of the study was to evaluate the relationship between carotid intima-media thickness (cIMT) and inflammatory markers plasma levels in OSA patients. We enrolled 80 OSA patients and 40 controls matched for age and body mass index (BMI). The presence and severity of sleep apnea was determined by in-laboratory portable monitoring (PM). Demographic data, blood pressure, heart rate, and cIMT were measured. High-sensitive C-Reactive Protein (hsCRP), interleukin (IL)-6, tumor necrosis factor (TNF)-α and pentraxin (PTX)-3 serum concentrations were detected. cIMT was higher in OSA patients than controls (0.89 ± 0.13 mm vs. 0.65 ± 0.1 mm, p < 0.01). Moderate-severe OSA patients (0.95 ± 0.09 mm) had significantly increased cIMT than mild OSA (0.76 ± 0.1 mm; p < 0.01) and control (0.65 ± 0.1 mm; p < 0.01). hsCRP, IL-6, TNF-α, and PTX-3 in patients with OSA (1.67 ± 0.66 mg/L, 2.86 ± 1.39 pg/mL, 20.09 ± 5.39 pg/mL, 2.1 ± 0.59 ng/mL, respectively) were significantly higher than in controls (1.08 ± 0.53 mg/L, p < 0.01; 1.5 ± 0.67 pg/mL, p < 0.01; 12.53 ± 3.48 pg/mL, p < 0.01; 1.45 ± 0.41 ng/mL, p < 0.01, respectively). Carotid IMT was significantly correlated to CRP (r = 0.44; p < 0.01), IL-6 (r = 0.42; p < 0.01), TNF-α (r = 0.53; p < 0.01), and PTX-3 (r = 0.49; p < 0.01). OSA patients showed increased cIMT, CRP, IL-6, TNF-α, and PTX-3 levels. Inflammatory markers levels are correlated to cIMT in OSA patients. MDPI 2014-01-29 /pmc/articles/PMC6271201/ /pubmed/24481114 http://dx.doi.org/10.3390/molecules19021651 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Ciccone, Marco Matteo Scicchitano, Pietro Zito, Annapaola Cortese, Francesca Boninfante, Barbara Falcone, Vito Antonio Quaranta, Vitaliano Nicola Ventura, Valentina Anna Zucano, Antonietta Di Serio, Francesca Damiani, Mario Francesco Resta, Onofrio Correlation between Inflammatory Markers of Atherosclerosis and Carotid Intima-Media Thickness in Obstructive Sleep Apnea |
title | Correlation between Inflammatory Markers of Atherosclerosis and Carotid Intima-Media Thickness in Obstructive Sleep Apnea |
title_full | Correlation between Inflammatory Markers of Atherosclerosis and Carotid Intima-Media Thickness in Obstructive Sleep Apnea |
title_fullStr | Correlation between Inflammatory Markers of Atherosclerosis and Carotid Intima-Media Thickness in Obstructive Sleep Apnea |
title_full_unstemmed | Correlation between Inflammatory Markers of Atherosclerosis and Carotid Intima-Media Thickness in Obstructive Sleep Apnea |
title_short | Correlation between Inflammatory Markers of Atherosclerosis and Carotid Intima-Media Thickness in Obstructive Sleep Apnea |
title_sort | correlation between inflammatory markers of atherosclerosis and carotid intima-media thickness in obstructive sleep apnea |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271201/ https://www.ncbi.nlm.nih.gov/pubmed/24481114 http://dx.doi.org/10.3390/molecules19021651 |
work_keys_str_mv | AT cicconemarcomatteo correlationbetweeninflammatorymarkersofatherosclerosisandcarotidintimamediathicknessinobstructivesleepapnea AT scicchitanopietro correlationbetweeninflammatorymarkersofatherosclerosisandcarotidintimamediathicknessinobstructivesleepapnea AT zitoannapaola correlationbetweeninflammatorymarkersofatherosclerosisandcarotidintimamediathicknessinobstructivesleepapnea AT cortesefrancesca correlationbetweeninflammatorymarkersofatherosclerosisandcarotidintimamediathicknessinobstructivesleepapnea AT boninfantebarbara correlationbetweeninflammatorymarkersofatherosclerosisandcarotidintimamediathicknessinobstructivesleepapnea AT falconevitoantonio correlationbetweeninflammatorymarkersofatherosclerosisandcarotidintimamediathicknessinobstructivesleepapnea AT quarantavitalianonicola correlationbetweeninflammatorymarkersofatherosclerosisandcarotidintimamediathicknessinobstructivesleepapnea AT venturavalentinaanna correlationbetweeninflammatorymarkersofatherosclerosisandcarotidintimamediathicknessinobstructivesleepapnea AT zucanoantonietta correlationbetweeninflammatorymarkersofatherosclerosisandcarotidintimamediathicknessinobstructivesleepapnea AT diseriofrancesca correlationbetweeninflammatorymarkersofatherosclerosisandcarotidintimamediathicknessinobstructivesleepapnea AT damianimariofrancesco correlationbetweeninflammatorymarkersofatherosclerosisandcarotidintimamediathicknessinobstructivesleepapnea AT restaonofrio correlationbetweeninflammatorymarkersofatherosclerosisandcarotidintimamediathicknessinobstructivesleepapnea |