Cargando…
Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel α-Amino-β-Substituted-γ,γ-Disubstituted Butyric Acids
The convenient, high yielding and diastereoselective synthesis of α-amino-β-substituted-γ,γ-disubstituted butyric acid derivatives was carried out by a three-component tandem reaction of a chiral equivalent of nucleophilic glycine. The reaction was performed smoothly under mild conditions and enable...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271210/ https://www.ncbi.nlm.nih.gov/pubmed/24434695 http://dx.doi.org/10.3390/molecules19010826 |
| _version_ | 1783376875785027584 |
|---|---|
| author | Zhou, Rui Guo, Li Peng, Cheng He, Gu Ouyang, Liang Huang, Wei |
| author_facet | Zhou, Rui Guo, Li Peng, Cheng He, Gu Ouyang, Liang Huang, Wei |
| author_sort | Zhou, Rui |
| collection | PubMed |
| description | The convenient, high yielding and diastereoselective synthesis of α-amino-β-substituted-γ,γ-disubstituted butyric acid derivatives was carried out by a three-component tandem reaction of a chiral equivalent of nucleophilic glycine. The reaction was performed smoothly under mild conditions and enabled the construction of two or three adjacent chiral centers in one step, thus affording a novel and convenient route to α-amino-β-substituted-γ,γ-disubstituted butyric acid derivatives. |
| format | Online Article Text |
| id | pubmed-6271210 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-62712102018-12-20 Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel α-Amino-β-Substituted-γ,γ-Disubstituted Butyric Acids Zhou, Rui Guo, Li Peng, Cheng He, Gu Ouyang, Liang Huang, Wei Molecules Article The convenient, high yielding and diastereoselective synthesis of α-amino-β-substituted-γ,γ-disubstituted butyric acid derivatives was carried out by a three-component tandem reaction of a chiral equivalent of nucleophilic glycine. The reaction was performed smoothly under mild conditions and enabled the construction of two or three adjacent chiral centers in one step, thus affording a novel and convenient route to α-amino-β-substituted-γ,γ-disubstituted butyric acid derivatives. MDPI 2014-01-10 /pmc/articles/PMC6271210/ /pubmed/24434695 http://dx.doi.org/10.3390/molecules19010826 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| spellingShingle | Article Zhou, Rui Guo, Li Peng, Cheng He, Gu Ouyang, Liang Huang, Wei Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel α-Amino-β-Substituted-γ,γ-Disubstituted Butyric Acids |
| title | Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel α-Amino-β-Substituted-γ,γ-Disubstituted Butyric Acids |
| title_full | Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel α-Amino-β-Substituted-γ,γ-Disubstituted Butyric Acids |
| title_fullStr | Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel α-Amino-β-Substituted-γ,γ-Disubstituted Butyric Acids |
| title_full_unstemmed | Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel α-Amino-β-Substituted-γ,γ-Disubstituted Butyric Acids |
| title_short | Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel α-Amino-β-Substituted-γ,γ-Disubstituted Butyric Acids |
| title_sort | diastereoselective three-component reactions of chiral nickel(ii) glycinate for convenient synthesis of novel α-amino-β-substituted-γ,γ-disubstituted butyric acids |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271210/ https://www.ncbi.nlm.nih.gov/pubmed/24434695 http://dx.doi.org/10.3390/molecules19010826 |
| work_keys_str_mv | AT zhourui diastereoselectivethreecomponentreactionsofchiralnickeliiglycinateforconvenientsynthesisofnovelaaminobsubstitutedggdisubstitutedbutyricacids AT guoli diastereoselectivethreecomponentreactionsofchiralnickeliiglycinateforconvenientsynthesisofnovelaaminobsubstitutedggdisubstitutedbutyricacids AT pengcheng diastereoselectivethreecomponentreactionsofchiralnickeliiglycinateforconvenientsynthesisofnovelaaminobsubstitutedggdisubstitutedbutyricacids AT hegu diastereoselectivethreecomponentreactionsofchiralnickeliiglycinateforconvenientsynthesisofnovelaaminobsubstitutedggdisubstitutedbutyricacids AT ouyangliang diastereoselectivethreecomponentreactionsofchiralnickeliiglycinateforconvenientsynthesisofnovelaaminobsubstitutedggdisubstitutedbutyricacids AT huangwei diastereoselectivethreecomponentreactionsofchiralnickeliiglycinateforconvenientsynthesisofnovelaaminobsubstitutedggdisubstitutedbutyricacids |