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Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer
MicroRNAs (miRNAs), the 17- to 25-nucleotide long noncoding RNAs that modulate the expression of mRNAs and proteins, have emerged as critical players in cancer initiation and progression processes. Deregulation of tissue miRNA expression levels associated with specific genetic alterations has been d...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271223/ https://www.ncbi.nlm.nih.gov/pubmed/24518808 http://dx.doi.org/10.3390/molecules19021912 |
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author | Wang, Jin Zhang, Ke-Yong Liu, Song-Mei Sen, Subrata |
author_facet | Wang, Jin Zhang, Ke-Yong Liu, Song-Mei Sen, Subrata |
author_sort | Wang, Jin |
collection | PubMed |
description | MicroRNAs (miRNAs), the 17- to 25-nucleotide long noncoding RNAs that modulate the expression of mRNAs and proteins, have emerged as critical players in cancer initiation and progression processes. Deregulation of tissue miRNA expression levels associated with specific genetic alterations has been demonstrated in cancer, where miRNAs function either as oncogenes or as tumor-suppressor genes and are shed from cancer cells into circulation. The present review summarizes and evaluates recent advances in our understanding of the characteristics of tumor tissue miRNAs, circulating miRNAs, and the stability of miRNAs in tissues and their varying expression profiles in circulating tumor cells, and body fluids including blood plasma. These advances in knowledge have led to intense efforts towards discovery and validation of differentially expressing tumor-associated miRNAs as biomarkers and therapeutic targets of cancer. The development of tumor-specific miRNA signatures as cancer biomarkers detectable in malignant cells and body fluids should help with early detection and more effective therapeutic intervention for individual patients. |
format | Online Article Text |
id | pubmed-6271223 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62712232018-12-20 Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer Wang, Jin Zhang, Ke-Yong Liu, Song-Mei Sen, Subrata Molecules Review MicroRNAs (miRNAs), the 17- to 25-nucleotide long noncoding RNAs that modulate the expression of mRNAs and proteins, have emerged as critical players in cancer initiation and progression processes. Deregulation of tissue miRNA expression levels associated with specific genetic alterations has been demonstrated in cancer, where miRNAs function either as oncogenes or as tumor-suppressor genes and are shed from cancer cells into circulation. The present review summarizes and evaluates recent advances in our understanding of the characteristics of tumor tissue miRNAs, circulating miRNAs, and the stability of miRNAs in tissues and their varying expression profiles in circulating tumor cells, and body fluids including blood plasma. These advances in knowledge have led to intense efforts towards discovery and validation of differentially expressing tumor-associated miRNAs as biomarkers and therapeutic targets of cancer. The development of tumor-specific miRNA signatures as cancer biomarkers detectable in malignant cells and body fluids should help with early detection and more effective therapeutic intervention for individual patients. MDPI 2014-02-10 /pmc/articles/PMC6271223/ /pubmed/24518808 http://dx.doi.org/10.3390/molecules19021912 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Wang, Jin Zhang, Ke-Yong Liu, Song-Mei Sen, Subrata Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer |
title | Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer |
title_full | Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer |
title_fullStr | Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer |
title_full_unstemmed | Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer |
title_short | Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer |
title_sort | tumor-associated circulating micrornas as biomarkers of cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271223/ https://www.ncbi.nlm.nih.gov/pubmed/24518808 http://dx.doi.org/10.3390/molecules19021912 |
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