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Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer

MicroRNAs (miRNAs), the 17- to 25-nucleotide long noncoding RNAs that modulate the expression of mRNAs and proteins, have emerged as critical players in cancer initiation and progression processes. Deregulation of tissue miRNA expression levels associated with specific genetic alterations has been d...

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Detalles Bibliográficos
Autores principales: Wang, Jin, Zhang, Ke-Yong, Liu, Song-Mei, Sen, Subrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271223/
https://www.ncbi.nlm.nih.gov/pubmed/24518808
http://dx.doi.org/10.3390/molecules19021912
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author Wang, Jin
Zhang, Ke-Yong
Liu, Song-Mei
Sen, Subrata
author_facet Wang, Jin
Zhang, Ke-Yong
Liu, Song-Mei
Sen, Subrata
author_sort Wang, Jin
collection PubMed
description MicroRNAs (miRNAs), the 17- to 25-nucleotide long noncoding RNAs that modulate the expression of mRNAs and proteins, have emerged as critical players in cancer initiation and progression processes. Deregulation of tissue miRNA expression levels associated with specific genetic alterations has been demonstrated in cancer, where miRNAs function either as oncogenes or as tumor-suppressor genes and are shed from cancer cells into circulation. The present review summarizes and evaluates recent advances in our understanding of the characteristics of tumor tissue miRNAs, circulating miRNAs, and the stability of miRNAs in tissues and their varying expression profiles in circulating tumor cells, and body fluids including blood plasma. These advances in knowledge have led to intense efforts towards discovery and validation of differentially expressing tumor-associated miRNAs as biomarkers and therapeutic targets of cancer. The development of tumor-specific miRNA signatures as cancer biomarkers detectable in malignant cells and body fluids should help with early detection and more effective therapeutic intervention for individual patients.
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spelling pubmed-62712232018-12-20 Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer Wang, Jin Zhang, Ke-Yong Liu, Song-Mei Sen, Subrata Molecules Review MicroRNAs (miRNAs), the 17- to 25-nucleotide long noncoding RNAs that modulate the expression of mRNAs and proteins, have emerged as critical players in cancer initiation and progression processes. Deregulation of tissue miRNA expression levels associated with specific genetic alterations has been demonstrated in cancer, where miRNAs function either as oncogenes or as tumor-suppressor genes and are shed from cancer cells into circulation. The present review summarizes and evaluates recent advances in our understanding of the characteristics of tumor tissue miRNAs, circulating miRNAs, and the stability of miRNAs in tissues and their varying expression profiles in circulating tumor cells, and body fluids including blood plasma. These advances in knowledge have led to intense efforts towards discovery and validation of differentially expressing tumor-associated miRNAs as biomarkers and therapeutic targets of cancer. The development of tumor-specific miRNA signatures as cancer biomarkers detectable in malignant cells and body fluids should help with early detection and more effective therapeutic intervention for individual patients. MDPI 2014-02-10 /pmc/articles/PMC6271223/ /pubmed/24518808 http://dx.doi.org/10.3390/molecules19021912 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Wang, Jin
Zhang, Ke-Yong
Liu, Song-Mei
Sen, Subrata
Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer
title Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer
title_full Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer
title_fullStr Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer
title_full_unstemmed Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer
title_short Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer
title_sort tumor-associated circulating micrornas as biomarkers of cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271223/
https://www.ncbi.nlm.nih.gov/pubmed/24518808
http://dx.doi.org/10.3390/molecules19021912
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