Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth

One new flavonoid named (2R,3R)-7-O-galloylplumbocatechin A (1) and three known flavonoids, (−)-5,3',4',5'-tetrahydroxyflavan-7-gallate (2), (+)-3,5,3',4',5'-penta-hydroxyflavan-7-gallate (3), and (−)-7,4'-di-O-galloyltricetiflavan (4), were isolated from Pithecell...

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Detalles Bibliográficos
Autores principales: Kang, Jie, Liu, Chao, Wang, Hongqing, Li, Baoming, Li, Chao, Chen, Ruoyun, Liu, Ailin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271231/
https://www.ncbi.nlm.nih.gov/pubmed/24727419
http://dx.doi.org/10.3390/molecules19044479
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author Kang, Jie
Liu, Chao
Wang, Hongqing
Li, Baoming
Li, Chao
Chen, Ruoyun
Liu, Ailin
author_facet Kang, Jie
Liu, Chao
Wang, Hongqing
Li, Baoming
Li, Chao
Chen, Ruoyun
Liu, Ailin
author_sort Kang, Jie
collection PubMed
description One new flavonoid named (2R,3R)-7-O-galloylplumbocatechin A (1) and three known flavonoids, (−)-5,3',4',5'-tetrahydroxyflavan-7-gallate (2), (+)-3,5,3',4',5'-penta-hydroxyflavan-7-gallate (3), and (−)-7,4'-di-O-galloyltricetiflavan (4), were isolated from Pithecellobium clypearia Benth. Their structures were elucidated based on spectroscopic analysis, including homonuclear and heteronuclear correlation NMR (HSQC and HMBC) experiments. In vitro assays, compounds 1 and 2 showed moderate inhibitory effects against influenza H1N1 virus neuraminidase (NA). Compounds 1–4 were all found to inhibit the expression of proinflammatory cytokines IL-6 or MCP-1 induced by influenza H1N1 virus in human A549 lung carcinoma cells.
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spelling pubmed-62712312019-01-02 Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth Kang, Jie Liu, Chao Wang, Hongqing Li, Baoming Li, Chao Chen, Ruoyun Liu, Ailin Molecules Article One new flavonoid named (2R,3R)-7-O-galloylplumbocatechin A (1) and three known flavonoids, (−)-5,3',4',5'-tetrahydroxyflavan-7-gallate (2), (+)-3,5,3',4',5'-penta-hydroxyflavan-7-gallate (3), and (−)-7,4'-di-O-galloyltricetiflavan (4), were isolated from Pithecellobium clypearia Benth. Their structures were elucidated based on spectroscopic analysis, including homonuclear and heteronuclear correlation NMR (HSQC and HMBC) experiments. In vitro assays, compounds 1 and 2 showed moderate inhibitory effects against influenza H1N1 virus neuraminidase (NA). Compounds 1–4 were all found to inhibit the expression of proinflammatory cytokines IL-6 or MCP-1 induced by influenza H1N1 virus in human A549 lung carcinoma cells. MDPI 2014-04-10 /pmc/articles/PMC6271231/ /pubmed/24727419 http://dx.doi.org/10.3390/molecules19044479 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kang, Jie
Liu, Chao
Wang, Hongqing
Li, Baoming
Li, Chao
Chen, Ruoyun
Liu, Ailin
Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth
title Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth
title_full Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth
title_fullStr Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth
title_full_unstemmed Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth
title_short Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth
title_sort studies on the bioactive flavonoids isolated from pithecellobium clypearia benth
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271231/
https://www.ncbi.nlm.nih.gov/pubmed/24727419
http://dx.doi.org/10.3390/molecules19044479
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