Cargando…
Several Human Cyclin-Dependent Kinase Inhibitors, Structurally Related to Roscovitine, As New Anti-Malarial Agents
In Africa, malaria kills one child each minute. It is also responsible for about one million deaths worldwide each year. Plasmodium falciparum, is the protozoan responsible for the most lethal form of the disease, with resistance developing against the available anti-malarial drugs. Among newly prop...
Autores principales: | Houzé, Sandrine, Hoang, Nha-Thu, Lozach, Olivier, Le Bras, Jacques, Meijer, Laurent, Galons, Hervé, Demange, Luc |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271241/ https://www.ncbi.nlm.nih.gov/pubmed/25251193 http://dx.doi.org/10.3390/molecules190915237 |
Ejemplares similares
-
A Simple Isomerization of the Purine Scaffold of a
Kinase Inhibitor, Roscovitine, Affords a Four- to Seven-Fold Enhancement
of Its Affinity for Four CDKs. Could This Be Traced Back to Conjugation-Induced
Stiffenings/Loosenings of Rotational Barriers?
por: El Hage, Krystel, et al.
Publicado: (2017) -
Antitumoral effects of cyclin-dependent kinases inhibitors CR8 and MR4 on chronic myeloid leukemia cell lines
por: Troadec, Samuel, et al.
Publicado: (2015) -
CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD
por: Bukanov, Nikolay O., et al.
Publicado: (2012) -
The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice
por: Rabhi, Nabil, et al.
Publicado: (2021) -
Human embryonic stem cells display a pronounced sensitivity to the cyclin dependent kinase inhibitor Roscovitine
por: Videla-Richardson, Guillermo A., et al.
Publicado: (2019)