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Ruthenium Complexes as NO Donors for Vascular Relaxation Induction

Nitric oxide (NO) donors are substances that can release NO. Vascular relaxation induction is among the several functions of NO, and the administration of NO donors is a pharmacological alternative to treat hypertension. This review will focus on the physicochemical description of ruthenium-derived...

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Autores principales: Galvão de Lima, Renata, Rodrigues Silva, Bruno, Santana da Silva, Roberto, Maria Bendhack, Lusiane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271244/
https://www.ncbi.nlm.nih.gov/pubmed/25004072
http://dx.doi.org/10.3390/molecules19079628
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author Galvão de Lima, Renata
Rodrigues Silva, Bruno
Santana da Silva, Roberto
Maria Bendhack, Lusiane
author_facet Galvão de Lima, Renata
Rodrigues Silva, Bruno
Santana da Silva, Roberto
Maria Bendhack, Lusiane
author_sort Galvão de Lima, Renata
collection PubMed
description Nitric oxide (NO) donors are substances that can release NO. Vascular relaxation induction is among the several functions of NO, and the administration of NO donors is a pharmacological alternative to treat hypertension. This review will focus on the physicochemical description of ruthenium-derived NO donor complexes that release NO via reduction and light stimulation. In particular, we will discuss the complexes synthesized by our research group over the last ten years, and we will focus on the vasodilation and arterial pressure control elicited by these complexes. Soluble guanylyl cyclase (sGC) and potassium channels are the main targets of the NO species released from the inorganic compounds. We will consider the importance of the chemical structure of the ruthenium complexes and their vascular effects.
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spelling pubmed-62712442018-12-21 Ruthenium Complexes as NO Donors for Vascular Relaxation Induction Galvão de Lima, Renata Rodrigues Silva, Bruno Santana da Silva, Roberto Maria Bendhack, Lusiane Molecules Review Nitric oxide (NO) donors are substances that can release NO. Vascular relaxation induction is among the several functions of NO, and the administration of NO donors is a pharmacological alternative to treat hypertension. This review will focus on the physicochemical description of ruthenium-derived NO donor complexes that release NO via reduction and light stimulation. In particular, we will discuss the complexes synthesized by our research group over the last ten years, and we will focus on the vasodilation and arterial pressure control elicited by these complexes. Soluble guanylyl cyclase (sGC) and potassium channels are the main targets of the NO species released from the inorganic compounds. We will consider the importance of the chemical structure of the ruthenium complexes and their vascular effects. MDPI 2014-07-07 /pmc/articles/PMC6271244/ /pubmed/25004072 http://dx.doi.org/10.3390/molecules19079628 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Galvão de Lima, Renata
Rodrigues Silva, Bruno
Santana da Silva, Roberto
Maria Bendhack, Lusiane
Ruthenium Complexes as NO Donors for Vascular Relaxation Induction
title Ruthenium Complexes as NO Donors for Vascular Relaxation Induction
title_full Ruthenium Complexes as NO Donors for Vascular Relaxation Induction
title_fullStr Ruthenium Complexes as NO Donors for Vascular Relaxation Induction
title_full_unstemmed Ruthenium Complexes as NO Donors for Vascular Relaxation Induction
title_short Ruthenium Complexes as NO Donors for Vascular Relaxation Induction
title_sort ruthenium complexes as no donors for vascular relaxation induction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271244/
https://www.ncbi.nlm.nih.gov/pubmed/25004072
http://dx.doi.org/10.3390/molecules19079628
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