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Design, Synthesis and SAR Study of Novel Trisubstituted Pyrimidine Amide Derivatives as CCR4 Antagonists
The design, synthesis and structure-activity relationship studies of some novel trisubstituted pyrimidine amide derivatives prepared as CCR4 antagonists are described. The activities of these compounds were evaluated by the CCR4-MDC chemotaxis inhibition assay. Compound 1, which we have previously r...
Autores principales: | Xu, Libao, Zhang, Yang, Dai, Wenjie, Wang, Ying, Jiang, Dan, Wang, Lili, Xiao, Junhai, Yang, Xiaohong, Li, Song |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271259/ https://www.ncbi.nlm.nih.gov/pubmed/24662072 http://dx.doi.org/10.3390/molecules19033539 |
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