Cargando…

Synthesis and Cytotoxicity Evaluation of Naphthalimide Derived N-Mustards

A series of N-mustards, which was conjugated to mono- or bis-naphthalimides with a flexible amine link, were synthesized and evaluated for cytotoxicity against five cancer cell lines (HCT-116, PC-3, U87 MG, Hep G2 and SK-OV-3). Several compounds displayed better activities than the control compound...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lou, Qinghua, Ji, Liyan, Zhong, Wenhe, Li, Shasha, Yu, Siwang, Li, Zhongjun, Meng, Xiangbao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271267/ https://www.ncbi.nlm.nih.gov/pubmed/24968335 http://dx.doi.org/10.3390/molecules19078803

Ejemplares similares

A novel triazolonaphthalimide induces apoptosis and inhibits tumor growth by targeting DNA and DNA-associated processes
por: Ji, Liyan, et al.
Publicado: (2017)

The Novel Triazolonaphthalimide Derivative LSS-11 Synergizes the Anti-Proliferative Effect of Paclitaxel via STAT3-Dependent MDR1 and MRP1 Downregulation in Chemoresistant Lung Cancer Cells
por: Ji, Liyan, et al.
Publicado: (2017)

Synthesis of 3-N-Sugar-substituted-2, 4(1H, 3H)-quinazolinediones as Anti-Angiogenesis Agents
por: Huang, Conghai, et al.
Publicado: (2009)

Synthesis and photobiological applications of naphthalimide–benzothiazole conjugates: cytotoxicity and topoisomerase IIα inhibition
por: Singh, Iqubal, et al.
Publicado: (2021)

Synthesis and characterization of naphthalimide-functionalized polynorbornenes
por: Hollauf, Manuel, et al.
Publicado: (2016)

Design, Synthesis and Evaluation of Naphthalimide Derivatives as Potential Anticancer Agents for Hepatocellular Carcinoma
por: Ge, Chaochao, et al.
Publicado: (2017)

Study on the Synthesis, Biological Activity and Spectroscopy of Naphthalimide-Diamine Conjugates
por: Tian, Zhi-Yong, et al.
Publicado: (2014)

The Synthesis and Antitumor Activity of 1,8-Naphthalimide Derivatives Linked 1,2,3-Triazole
por: Xu, Zhong-jie, et al.
Publicado: (2021)

Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives and Analogs Targeting the NLRP3 Inflammasome
por: Pan, Liangkun, et al.
Publicado: (2017)

Synthesis of nitrogen mustard-based fluorophores for cell imaging and cytotoxicity studies
por: Liang, Yuanwei, et al.
Publicado: (2023)

Synthesis, Photophysical Characterization, and Sensor Activity of New 1,8-Naphthalimide Derivatives
por: Yordanova-Tomova, Stanislava, et al.
Publicado: (2020)

Method for the synthesis of flavonoid nitrogen mustard derivatives
por: Song, Jinglei, et al.
Publicado: (2020)

Design and synthesis of naphthalimide group-bearing thioglycosides as novel β-N-acetylhexosaminidases inhibitors
por: Shen, Shengqiang, et al.
Publicado: (2018)

Design, Synthesis and Antifibrotic Activities of Carbohydrate- Modified 1-(Substituted aryl)-5-trifluoromethyl-2(1H) Pyridones
por: Lou, Qinghua, et al.
Publicado: (2012)

Experimental and computational study of naphthalimide derivatives: Synthesis, optical, nonlinear optical and antiviral properties
por: Kumar, Santosh, et al.
Publicado: (2021)

N-(2-Hydroxyethyl)-1,8-naphthalimide
por: Sun, Jie, et al.
Publicado: (2009)

N-(4-Chlorophenyl)-1,8-naphthalimide
por: Jie, Sun, et al.
Publicado: (2009)

Design, Synthesis, and Evaluation of Novel 3-Carboranyl-1,8-Naphthalimide Derivatives as Potential Anticancer Agents
por: Rykowski, Sebastian, et al.
Publicado: (2021)

N-(4-Aminophenyl)-1,8-naphthalimide hemihydrate
por: Jian, Fang-Fang, et al.
Publicado: (2007)

Optimized Synthesis of New N-Mustards Based on 2-Mercaptobenzoxazole Derivatives with Antitumor Activity
por: Cheptea, Corina, et al.
Publicado: (2021)

Synthesis, DNA Binding, and Anticancer Properties of Bis-Naphthalimide Derivatives with Lysine-Modified Polyamine Linkers
por: Huang, Yu, et al.
Publicado: (2018)

Synthesis and Solvent Dependent Fluorescence of Some Piperidine-Substituted Naphthalimide Derivatives and Consequences for Water Sensing
por: Tigoianu, Radu, et al.
Publicado: (2022)

Design, Synthesis, and Antitumor Activity Evaluation of Proteolysis-Targeting Chimeras as Degraders of Extracellular Signal-Regulated Kinases 1/2
por: Pan, Pengming, et al.
Publicado: (2023)

Dual-Emissive Waterborne Polyurethanes Prepared from Naphthalimide Derivative
por: Wang, Tao, et al.
Publicado: (2017)

Design and synthesis of chromone-nitrogen mustard derivatives and evaluation of anti-breast cancer activity
por: Sun, Jianan, et al.
Publicado: (2021)

Synthesis and Evaluation of 1,8‐Disubstituted‐Cyclam/Naphthalimide Conjugates as Probes for Metal Ions
por: Wong, Joseph K.‐H., et al.
Publicado: (2016)

Synthesis of naphthalimide-type chemsensor and its application in quality evaluation for polygonatum sibiricum Red
por: Wang, Zhen, et al.
Publicado: (2022)

N-Methacryloyl-4-(piperidin-1-yl)-1,8-naphthalimide
por: Hanton, Lyall R., et al.
Publicado: (2010)

Synthesis, FTIR, (13)C-NMR and Temperature-Dependent (1)HNMR Characteristics of Bis-naphthalimide Derivatives
por: Grzesiak, Waldemar, et al.
Publicado: (2012)

Synthesis and Fluorescent Property Study of Novel 1,8-Naphthalimide-Based Chemosensors
por: Fu, Ying, et al.
Publicado: (2018)

Synthesis and Cytotoxicity Evaluation of Tropinone Derivatives
por: Yin, Xiu-Juan, et al.
Publicado: (2017)

A Pyridine-Containing Cu(2+)-Selective Probe Based on Naphthalimide Derivative
por: Zhang, Jun, et al.
Publicado: (2014)

Synthesis and Cytotoxic Evaluation of Novel N-Methyl-4-phenoxypicolinamide Derivatives
por: Li, Wei, et al.
Publicado: (2011)

Micellar effects and analytical applications of nitro substitution in 4-Nitro-N-alkyl-1,8-naphthalimide by cysteine derivatives
por: Martins, V.S., et al.
Publicado: (2020)

Synthesis of 1,8-naphthalimide-based probes with fluorescent switch triggered by flufenamic acid
por: Saito, G., et al.
Publicado: (2018)

Rational Design and Synthesis of Naphthalene Diimide Linked Bis-Naphthalimides as DNA Interactive Agents
por: Malik, M. Shaheer, et al.
Publicado: (2021)

Synthesis and in vitro anti-proliferative evaluation of naphthalimide–chalcone/pyrazoline conjugates as potential SERMs with computational validation
por: Shalini,, et al.
Publicado: (2020)

Versatile naphthalimide tetrazines for fluorogenic bioorthogonal labelling
por: Graziotto, Marcus E., et al.
Publicado: (2021)

Luminescence and Electrochemical Activity of New Unsymmetrical 3-Imino-1,8-naphthalimide Derivatives
por: Kotowicz, Sonia, et al.
Publicado: (2021)

Metallocene-Naphthalimide Derivatives: The Effect of Geometry, DFT Methodology, and Transition Metals on Absorption Spectra
por: Tzeliou, Christina Eleftheria, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_mmbc47t271v5j099qigmubppce