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Synthesis, Leishmanicidal Activity and Theoretical Evaluations of a Series of Substituted bis-2-Hydroxy-1,4-Naphthoquinones
A series of eight substituted bis-2-hydroxy-1,4-naphthoquinone derivatives was synthesized through lawsone condensation with various aromatic and aliphatic aldehydes under mild acidic conditions. The title compounds were evaluated for antileishmanial activity in vitro against Leishmania amazonensis...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271274/ https://www.ncbi.nlm.nih.gov/pubmed/25247686 http://dx.doi.org/10.3390/molecules190915180 |
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| author | de Araújo, Morgana V. de Souza, Patricia S. O. de Queiroz, Aline C. da Matta, Carolina B. B. Leite, Anderson Brandão da Silva, Amanda Evelyn de França, José A. A. Silva, Tania M. S. Camara, Celso A. Alexandre-Moreira, Magna S. |
| author_facet | de Araújo, Morgana V. de Souza, Patricia S. O. de Queiroz, Aline C. da Matta, Carolina B. B. Leite, Anderson Brandão da Silva, Amanda Evelyn de França, José A. A. Silva, Tania M. S. Camara, Celso A. Alexandre-Moreira, Magna S. |
| author_sort | de Araújo, Morgana V. |
| collection | PubMed |
| description | A series of eight substituted bis-2-hydroxy-1,4-naphthoquinone derivatives was synthesized through lawsone condensation with various aromatic and aliphatic aldehydes under mild acidic conditions. The title compounds were evaluated for antileishmanial activity in vitro against Leishmania amazonensis and Leishmania braziliensis promastigotes; six compounds showed good activity without significant toxic effects. The compound with the highest activity was used for an in vivo assay with Leishmania amazonensis. |
| format | Online Article Text |
| id | pubmed-6271274 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-62712742018-12-27 Synthesis, Leishmanicidal Activity and Theoretical Evaluations of a Series of Substituted bis-2-Hydroxy-1,4-Naphthoquinones de Araújo, Morgana V. de Souza, Patricia S. O. de Queiroz, Aline C. da Matta, Carolina B. B. Leite, Anderson Brandão da Silva, Amanda Evelyn de França, José A. A. Silva, Tania M. S. Camara, Celso A. Alexandre-Moreira, Magna S. Molecules Article A series of eight substituted bis-2-hydroxy-1,4-naphthoquinone derivatives was synthesized through lawsone condensation with various aromatic and aliphatic aldehydes under mild acidic conditions. The title compounds were evaluated for antileishmanial activity in vitro against Leishmania amazonensis and Leishmania braziliensis promastigotes; six compounds showed good activity without significant toxic effects. The compound with the highest activity was used for an in vivo assay with Leishmania amazonensis. MDPI 2014-09-22 /pmc/articles/PMC6271274/ /pubmed/25247686 http://dx.doi.org/10.3390/molecules190915180 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| spellingShingle | Article de Araújo, Morgana V. de Souza, Patricia S. O. de Queiroz, Aline C. da Matta, Carolina B. B. Leite, Anderson Brandão da Silva, Amanda Evelyn de França, José A. A. Silva, Tania M. S. Camara, Celso A. Alexandre-Moreira, Magna S. Synthesis, Leishmanicidal Activity and Theoretical Evaluations of a Series of Substituted bis-2-Hydroxy-1,4-Naphthoquinones |
| title | Synthesis, Leishmanicidal Activity and Theoretical Evaluations of a Series of Substituted bis-2-Hydroxy-1,4-Naphthoquinones |
| title_full | Synthesis, Leishmanicidal Activity and Theoretical Evaluations of a Series of Substituted bis-2-Hydroxy-1,4-Naphthoquinones |
| title_fullStr | Synthesis, Leishmanicidal Activity and Theoretical Evaluations of a Series of Substituted bis-2-Hydroxy-1,4-Naphthoquinones |
| title_full_unstemmed | Synthesis, Leishmanicidal Activity and Theoretical Evaluations of a Series of Substituted bis-2-Hydroxy-1,4-Naphthoquinones |
| title_short | Synthesis, Leishmanicidal Activity and Theoretical Evaluations of a Series of Substituted bis-2-Hydroxy-1,4-Naphthoquinones |
| title_sort | synthesis, leishmanicidal activity and theoretical evaluations of a series of substituted bis-2-hydroxy-1,4-naphthoquinones |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271274/ https://www.ncbi.nlm.nih.gov/pubmed/25247686 http://dx.doi.org/10.3390/molecules190915180 |
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