Playing with Opening and Closing of Heterocycles: Using the Cusmano-Ruccia Reaction to Develop a Novel Class of Oxadiazolothiazinones, Active as Calcium Channel Modulators and P-Glycoprotein Inhibitors

As a result of the ring-into-ring conversion of nitrosoimidazole derivatives, we obtained a molecular scaffold that, when properly decorated, is able to decrease inotropy by blocking L-type calcium channels. Previously, we used this scaffold to develop a quantitative structure-activity relationship...

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Detalles Bibliográficos
Autores principales: Spinelli, Domenico, Budriesi, Roberta, Cosimelli, Barbara, Severi, Elda, Micucci, Matteo, Baroni, Massimo, Fusi, Fabio, Ioan, Pierfranco, Cross, Simon, Frosini, Maria, Saponara, Simona, Matucci, Rosanna, Rosano, Camillo, Viale, Maurizio, Chiarini, Alberto, Carosati, Emanuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271282/
https://www.ncbi.nlm.nih.gov/pubmed/25317581
http://dx.doi.org/10.3390/molecules191016543

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