Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids

Cell-free circulating microRNAs (miRNAs) in the blood are good diagnostic biomarker candidates for various physiopathological conditions, including cancer, neurodegeneration, diabetes and other diseases. Since their discovery in 2008 as blood biomarkers, the field has expanded rapidly with a number...

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Detalles Bibliográficos
Autores principales: Chevillet, John R., Lee, Inyoul, Briggs, Hilary A., He, Yuqing, Wang, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271291/
https://www.ncbi.nlm.nih.gov/pubmed/24830712
http://dx.doi.org/10.3390/molecules19056080
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author Chevillet, John R.
Lee, Inyoul
Briggs, Hilary A.
He, Yuqing
Wang, Kai
author_facet Chevillet, John R.
Lee, Inyoul
Briggs, Hilary A.
He, Yuqing
Wang, Kai
author_sort Chevillet, John R.
collection PubMed
description Cell-free circulating microRNAs (miRNAs) in the blood are good diagnostic biomarker candidates for various physiopathological conditions, including cancer, neurodegeneration, diabetes and other diseases. Since their discovery in 2008 as blood biomarkers, the field has expanded rapidly with a number of important findings. Despite the initial optimistic views of their potential for clinical application, there are currently no circulating miRNA-based diagnostics in use. In this article, we review the status of circulating miRNAs, examine different analytical approaches, and address some of the challenges and opportunities.
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spelling pubmed-62712912018-12-21 Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids Chevillet, John R. Lee, Inyoul Briggs, Hilary A. He, Yuqing Wang, Kai Molecules Review Cell-free circulating microRNAs (miRNAs) in the blood are good diagnostic biomarker candidates for various physiopathological conditions, including cancer, neurodegeneration, diabetes and other diseases. Since their discovery in 2008 as blood biomarkers, the field has expanded rapidly with a number of important findings. Despite the initial optimistic views of their potential for clinical application, there are currently no circulating miRNA-based diagnostics in use. In this article, we review the status of circulating miRNAs, examine different analytical approaches, and address some of the challenges and opportunities. MDPI 2014-05-14 /pmc/articles/PMC6271291/ /pubmed/24830712 http://dx.doi.org/10.3390/molecules19056080 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Chevillet, John R.
Lee, Inyoul
Briggs, Hilary A.
He, Yuqing
Wang, Kai
Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids
title Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids
title_full Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids
title_fullStr Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids
title_full_unstemmed Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids
title_short Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids
title_sort issues and prospects of microrna-based biomarkers in blood and other body fluids
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271291/
https://www.ncbi.nlm.nih.gov/pubmed/24830712
http://dx.doi.org/10.3390/molecules19056080
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