Development of an estimated glomerular filtration rate formula in cats
BACKGROUND: Estimated glomerular filtration rate (eGFR) formulas are routinely used in human patients to provide a more accurate evaluation of GFR compared to serum creatinine concentration alone. Similar formulas do not exist for cats. OBJECTIVES: To validate a prediction formula for eGFR in cats b...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271324/ https://www.ncbi.nlm.nih.gov/pubmed/30378177 http://dx.doi.org/10.1111/jvim.15325 |
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author | Finch, Natalie C. Syme, Harriet M. Elliott, Jonathan |
author_facet | Finch, Natalie C. Syme, Harriet M. Elliott, Jonathan |
author_sort | Finch, Natalie C. |
collection | PubMed |
description | BACKGROUND: Estimated glomerular filtration rate (eGFR) formulas are routinely used in human patients to provide a more accurate evaluation of GFR compared to serum creatinine concentration alone. Similar formulas do not exist for cats. OBJECTIVES: To validate a prediction formula for eGFR in cats based on adjusting serum creatinine concentration. ANIMALS: Client‐owned cats with various levels of renal function. METHODS: The study was cross‐sectional. Glomerular filtration rate was determined by iohexol clearance. Variables including signalment, biochemical markers, and noninvasive measurements considered to represent surrogate markers of muscle mass were evaluated with the reciprocal of serum creatinine concentration in a multivariable regression model. The derived eGFR formula was subsequently tested in another group of cats and agreement with GFR assessed. RESULTS: The formula was developed in 55 cats. Only a single morphometric measurement (pelvic circumference) along with the reciprocal of serum creatinine concentration (creatinine(−1)) independently predicted GFR in the final multivariate model. The derived eGFR formula was 0.408 + (243.11 × creatinine(−1) [μmol/L]) ‐ (0.014 × pelvic circumference [cm]). When the formula was tested in another 25 cats it was not found to offer any advantage over creatinine(−1) alone in its relationship with GFR (eGFR, R (2) = 0.44, P < .001 vs reciprocal of creatinine, R (2) = 0.45, P < .001). Furthermore, agreement between eGFR and GFR was poor. CONCLUSIONS AND CLINICAL IMPORTANCE: An eGFR formula for cats that adjusted serum creatinine concentration for a marker of muscle mass was developed. The formula did not provide a reliable estimate of GFR, and therefore, its routine use cannot be recommended. |
format | Online Article Text |
id | pubmed-6271324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62713242018-12-05 Development of an estimated glomerular filtration rate formula in cats Finch, Natalie C. Syme, Harriet M. Elliott, Jonathan J Vet Intern Med SMALL ANIMAL BACKGROUND: Estimated glomerular filtration rate (eGFR) formulas are routinely used in human patients to provide a more accurate evaluation of GFR compared to serum creatinine concentration alone. Similar formulas do not exist for cats. OBJECTIVES: To validate a prediction formula for eGFR in cats based on adjusting serum creatinine concentration. ANIMALS: Client‐owned cats with various levels of renal function. METHODS: The study was cross‐sectional. Glomerular filtration rate was determined by iohexol clearance. Variables including signalment, biochemical markers, and noninvasive measurements considered to represent surrogate markers of muscle mass were evaluated with the reciprocal of serum creatinine concentration in a multivariable regression model. The derived eGFR formula was subsequently tested in another group of cats and agreement with GFR assessed. RESULTS: The formula was developed in 55 cats. Only a single morphometric measurement (pelvic circumference) along with the reciprocal of serum creatinine concentration (creatinine(−1)) independently predicted GFR in the final multivariate model. The derived eGFR formula was 0.408 + (243.11 × creatinine(−1) [μmol/L]) ‐ (0.014 × pelvic circumference [cm]). When the formula was tested in another 25 cats it was not found to offer any advantage over creatinine(−1) alone in its relationship with GFR (eGFR, R (2) = 0.44, P < .001 vs reciprocal of creatinine, R (2) = 0.45, P < .001). Furthermore, agreement between eGFR and GFR was poor. CONCLUSIONS AND CLINICAL IMPORTANCE: An eGFR formula for cats that adjusted serum creatinine concentration for a marker of muscle mass was developed. The formula did not provide a reliable estimate of GFR, and therefore, its routine use cannot be recommended. John Wiley & Sons, Inc. 2018-10-30 2018 /pmc/articles/PMC6271324/ /pubmed/30378177 http://dx.doi.org/10.1111/jvim.15325 Text en © 2018 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | SMALL ANIMAL Finch, Natalie C. Syme, Harriet M. Elliott, Jonathan Development of an estimated glomerular filtration rate formula in cats |
title | Development of an estimated glomerular filtration rate formula in cats |
title_full | Development of an estimated glomerular filtration rate formula in cats |
title_fullStr | Development of an estimated glomerular filtration rate formula in cats |
title_full_unstemmed | Development of an estimated glomerular filtration rate formula in cats |
title_short | Development of an estimated glomerular filtration rate formula in cats |
title_sort | development of an estimated glomerular filtration rate formula in cats |
topic | SMALL ANIMAL |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271324/ https://www.ncbi.nlm.nih.gov/pubmed/30378177 http://dx.doi.org/10.1111/jvim.15325 |
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