Development of an estimated glomerular filtration rate formula in cats

BACKGROUND: Estimated glomerular filtration rate (eGFR) formulas are routinely used in human patients to provide a more accurate evaluation of GFR compared to serum creatinine concentration alone. Similar formulas do not exist for cats. OBJECTIVES: To validate a prediction formula for eGFR in cats b...

Descripción completa

Detalles Bibliográficos
Autores principales: Finch, Natalie C., Syme, Harriet M., Elliott, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271324/
https://www.ncbi.nlm.nih.gov/pubmed/30378177
http://dx.doi.org/10.1111/jvim.15325
_version_ 1783376902234308608
author Finch, Natalie C.
Syme, Harriet M.
Elliott, Jonathan
author_facet Finch, Natalie C.
Syme, Harriet M.
Elliott, Jonathan
author_sort Finch, Natalie C.
collection PubMed
description BACKGROUND: Estimated glomerular filtration rate (eGFR) formulas are routinely used in human patients to provide a more accurate evaluation of GFR compared to serum creatinine concentration alone. Similar formulas do not exist for cats. OBJECTIVES: To validate a prediction formula for eGFR in cats based on adjusting serum creatinine concentration. ANIMALS: Client‐owned cats with various levels of renal function. METHODS: The study was cross‐sectional. Glomerular filtration rate was determined by iohexol clearance. Variables including signalment, biochemical markers, and noninvasive measurements considered to represent surrogate markers of muscle mass were evaluated with the reciprocal of serum creatinine concentration in a multivariable regression model. The derived eGFR formula was subsequently tested in another group of cats and agreement with GFR assessed. RESULTS: The formula was developed in 55 cats. Only a single morphometric measurement (pelvic circumference) along with the reciprocal of serum creatinine concentration (creatinine(−1)) independently predicted GFR in the final multivariate model. The derived eGFR formula was 0.408 + (243.11 × creatinine(−1) [μmol/L]) ‐ (0.014 × pelvic circumference [cm]). When the formula was tested in another 25 cats it was not found to offer any advantage over creatinine(−1) alone in its relationship with GFR (eGFR, R (2) = 0.44, P < .001 vs reciprocal of creatinine, R (2) = 0.45, P < .001). Furthermore, agreement between eGFR and GFR was poor. CONCLUSIONS AND CLINICAL IMPORTANCE: An eGFR formula for cats that adjusted serum creatinine concentration for a marker of muscle mass was developed. The formula did not provide a reliable estimate of GFR, and therefore, its routine use cannot be recommended.
format Online
Article
Text
id pubmed-6271324
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher John Wiley & Sons, Inc.
record_format MEDLINE/PubMed
spelling pubmed-62713242018-12-05 Development of an estimated glomerular filtration rate formula in cats Finch, Natalie C. Syme, Harriet M. Elliott, Jonathan J Vet Intern Med SMALL ANIMAL BACKGROUND: Estimated glomerular filtration rate (eGFR) formulas are routinely used in human patients to provide a more accurate evaluation of GFR compared to serum creatinine concentration alone. Similar formulas do not exist for cats. OBJECTIVES: To validate a prediction formula for eGFR in cats based on adjusting serum creatinine concentration. ANIMALS: Client‐owned cats with various levels of renal function. METHODS: The study was cross‐sectional. Glomerular filtration rate was determined by iohexol clearance. Variables including signalment, biochemical markers, and noninvasive measurements considered to represent surrogate markers of muscle mass were evaluated with the reciprocal of serum creatinine concentration in a multivariable regression model. The derived eGFR formula was subsequently tested in another group of cats and agreement with GFR assessed. RESULTS: The formula was developed in 55 cats. Only a single morphometric measurement (pelvic circumference) along with the reciprocal of serum creatinine concentration (creatinine(−1)) independently predicted GFR in the final multivariate model. The derived eGFR formula was 0.408 + (243.11 × creatinine(−1) [μmol/L]) ‐ (0.014 × pelvic circumference [cm]). When the formula was tested in another 25 cats it was not found to offer any advantage over creatinine(−1) alone in its relationship with GFR (eGFR, R (2) = 0.44, P < .001 vs reciprocal of creatinine, R (2) = 0.45, P < .001). Furthermore, agreement between eGFR and GFR was poor. CONCLUSIONS AND CLINICAL IMPORTANCE: An eGFR formula for cats that adjusted serum creatinine concentration for a marker of muscle mass was developed. The formula did not provide a reliable estimate of GFR, and therefore, its routine use cannot be recommended. John Wiley & Sons, Inc. 2018-10-30 2018 /pmc/articles/PMC6271324/ /pubmed/30378177 http://dx.doi.org/10.1111/jvim.15325 Text en © 2018 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle SMALL ANIMAL
Finch, Natalie C.
Syme, Harriet M.
Elliott, Jonathan
Development of an estimated glomerular filtration rate formula in cats
title Development of an estimated glomerular filtration rate formula in cats
title_full Development of an estimated glomerular filtration rate formula in cats
title_fullStr Development of an estimated glomerular filtration rate formula in cats
title_full_unstemmed Development of an estimated glomerular filtration rate formula in cats
title_short Development of an estimated glomerular filtration rate formula in cats
title_sort development of an estimated glomerular filtration rate formula in cats
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271324/
https://www.ncbi.nlm.nih.gov/pubmed/30378177
http://dx.doi.org/10.1111/jvim.15325
work_keys_str_mv AT finchnataliec developmentofanestimatedglomerularfiltrationrateformulaincats
AT symeharrietm developmentofanestimatedglomerularfiltrationrateformulaincats
AT elliottjonathan developmentofanestimatedglomerularfiltrationrateformulaincats