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Isolation and Bioactivities of the Flavonoids Morin and Morin-3-O-β-D-glucopyranoside from Acridocarpus orientalis—A Wild Arabian Medicinal Plant
Acridocarpus orientalis is an important medicinal plant for some of the locals of Arabian region. Very little is known about its phytochemical constituents. In the present study, we aimed to isolate bioactive chemicals from the crude methanolic extract of the aerial parts of A. orientalis. The extra...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271336/ https://www.ncbi.nlm.nih.gov/pubmed/25421414 http://dx.doi.org/10.3390/molecules191117763 |
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author | Hussain, Javid Ali, Liaqat Khan, Abdul Latif Ur Rehman, Najeeb Jabeen, Farah Kim, Jong-Sang Al-Harrasi, Ahmed |
author_facet | Hussain, Javid Ali, Liaqat Khan, Abdul Latif Ur Rehman, Najeeb Jabeen, Farah Kim, Jong-Sang Al-Harrasi, Ahmed |
author_sort | Hussain, Javid |
collection | PubMed |
description | Acridocarpus orientalis is an important medicinal plant for some of the locals of Arabian region. Very little is known about its phytochemical constituents. In the present study, we aimed to isolate bioactive chemicals from the crude methanolic extract of the aerial parts of A. orientalis. The extraction and isolation resulted in the purification of two flavonoids: morin (1) and morin-3-O-β-D-glucopyranoside (2). The structure elucidation was carried out by extensive analysis of spectroscopic data and comparison with the reported data for the known constituents. The pure isolates were subjected to various biological assays for their bioactivities. The compounds 1 and 2 were significantly active against the growth of various pathogenic fungi and phytotoxic against lettuce seed at higher concentrations. Furthermore, the free radical scavenging activities, anti-lipid peroxidation, and cytotoxic effects against HepG2, HT29, and HCT116 cancer cell lines were also assayed and the results are presented in this paper. |
format | Online Article Text |
id | pubmed-6271336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62713362019-01-07 Isolation and Bioactivities of the Flavonoids Morin and Morin-3-O-β-D-glucopyranoside from Acridocarpus orientalis—A Wild Arabian Medicinal Plant Hussain, Javid Ali, Liaqat Khan, Abdul Latif Ur Rehman, Najeeb Jabeen, Farah Kim, Jong-Sang Al-Harrasi, Ahmed Molecules Communication Acridocarpus orientalis is an important medicinal plant for some of the locals of Arabian region. Very little is known about its phytochemical constituents. In the present study, we aimed to isolate bioactive chemicals from the crude methanolic extract of the aerial parts of A. orientalis. The extraction and isolation resulted in the purification of two flavonoids: morin (1) and morin-3-O-β-D-glucopyranoside (2). The structure elucidation was carried out by extensive analysis of spectroscopic data and comparison with the reported data for the known constituents. The pure isolates were subjected to various biological assays for their bioactivities. The compounds 1 and 2 were significantly active against the growth of various pathogenic fungi and phytotoxic against lettuce seed at higher concentrations. Furthermore, the free radical scavenging activities, anti-lipid peroxidation, and cytotoxic effects against HepG2, HT29, and HCT116 cancer cell lines were also assayed and the results are presented in this paper. MDPI 2014-10-31 /pmc/articles/PMC6271336/ /pubmed/25421414 http://dx.doi.org/10.3390/molecules191117763 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Hussain, Javid Ali, Liaqat Khan, Abdul Latif Ur Rehman, Najeeb Jabeen, Farah Kim, Jong-Sang Al-Harrasi, Ahmed Isolation and Bioactivities of the Flavonoids Morin and Morin-3-O-β-D-glucopyranoside from Acridocarpus orientalis—A Wild Arabian Medicinal Plant |
title | Isolation and Bioactivities of the Flavonoids Morin and Morin-3-O-β-D-glucopyranoside from Acridocarpus orientalis—A Wild Arabian Medicinal Plant |
title_full | Isolation and Bioactivities of the Flavonoids Morin and Morin-3-O-β-D-glucopyranoside from Acridocarpus orientalis—A Wild Arabian Medicinal Plant |
title_fullStr | Isolation and Bioactivities of the Flavonoids Morin and Morin-3-O-β-D-glucopyranoside from Acridocarpus orientalis—A Wild Arabian Medicinal Plant |
title_full_unstemmed | Isolation and Bioactivities of the Flavonoids Morin and Morin-3-O-β-D-glucopyranoside from Acridocarpus orientalis—A Wild Arabian Medicinal Plant |
title_short | Isolation and Bioactivities of the Flavonoids Morin and Morin-3-O-β-D-glucopyranoside from Acridocarpus orientalis—A Wild Arabian Medicinal Plant |
title_sort | isolation and bioactivities of the flavonoids morin and morin-3-o-β-d-glucopyranoside from acridocarpus orientalis—a wild arabian medicinal plant |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271336/ https://www.ncbi.nlm.nih.gov/pubmed/25421414 http://dx.doi.org/10.3390/molecules191117763 |
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