Three New Clerodane Diterpenes from Polyalthia longifolia var. pendula

Three new clerodane diterpenes, (4→2)-abeo-cleroda-2,13E-dien-2,14-dioic acid (1), (4→2)-abeo-2,13-diformyl-cleroda-2,13E-dien-14-oic acid (2), and 16(R&S)-methoxycleroda-4(18),13-dien-15,16-olide (3), were isolated from the unripe fruit of Polyalthia longifolia var. pendula (Annonaceae) togethe...

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Detalles Bibliográficos
Autores principales: Wu, Tung-Ho, Cheng, Yung-Yi, Chen, Chao-Jung, Ng, Lean-Teik, Chou, Li-Chen, Huang, Li-Jiau, Chen, Yung-Husan, Kuo, Sheng-Chu, El-Shazly, Mohamed, Wu, Yang-Chang, Chang, Fang-Rong, Liaw, Chih-Chuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271339/
https://www.ncbi.nlm.nih.gov/pubmed/24531220
http://dx.doi.org/10.3390/molecules19022049
Descripción
Sumario:Three new clerodane diterpenes, (4→2)-abeo-cleroda-2,13E-dien-2,14-dioic acid (1), (4→2)-abeo-2,13-diformyl-cleroda-2,13E-dien-14-oic acid (2), and 16(R&S)-methoxycleroda-4(18),13-dien-15,16-olide (3), were isolated from the unripe fruit of Polyalthia longifolia var. pendula (Annonaceae) together with five known compounds (4–8). The structures of all isolates were determined by spectroscopic analysis. The anti-inflammatory activity of the isolates was evaluated by testing their inhibitory effect on NO production in LPS-stimulated RAW 264.7 macrophages. Among the isolated compounds, 16-hydroxycleroda-3,13-dien-15,16-olide (6) and 16-oxocleroda-3,13-dien-15-oic acid (7) showed promising NO inhibitory activity at 10 µg/mL, with 81.1% and 86.3%, inhibition, respectively.

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