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A Greener, Efficient Approach to Michael Addition of Barbituric Acid to Nitroalkene in Aqueous Diethylamine Medium

An efficient method for the synthesis of a variety of pyrimidine derivatives 3a–t by reaction of barbituric acids 1a,b as Michael donor with nitroalkenes 2a–k as Michael acceptor using an aqueous medium and diethylamine is described. This 1,4-addition strategy offers several advantages, such as usin...

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Detalles Bibliográficos
Autores principales:	Al-Najjar, Hany J., Barakat, Assem, Al-Majid, Abdullah M., Mabkhot, Yahia N., Weber, Manuel, Ghabbour, Hazem A., Fun, Hoong-Kun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271361/ https://www.ncbi.nlm.nih.gov/pubmed/24445342 http://dx.doi.org/10.3390/molecules19011150

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Correction: Al-Majid, A.M., et al., Tandem Aldol-Michael Reactions in Aqueous Diethylamine Medium: A Greener and Efficient Approach to Bis-Pyrimidine Derivatives. Int. J. Mol. Sci. 2013, 14, 23762–23773.
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