Two New N-Oxide Alkaloids from Stemona cochinchinensis

Two new N-oxide alkaloids with pyrrolo[1,2-α]azepine skeleton, namely isoneostemocochinine-N-oxide (1) and neostemocochinine-N-oxide (2), as well as three known alkaloids with pyrido[1,2-α]azepine skeletons, were isolated and identified from the roots of Stemona cochinchinensis (Stemonaceae). The st...

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Autores principales: Lin, Ligen, Bao, Han, Wang, Anqi, Tang, Chunping, Dien, Pham-Huu, Ye, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271367/
https://www.ncbi.nlm.nih.gov/pubmed/25479189
http://dx.doi.org/10.3390/molecules191220257
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author Lin, Ligen
Bao, Han
Wang, Anqi
Tang, Chunping
Dien, Pham-Huu
Ye, Yang
author_facet Lin, Ligen
Bao, Han
Wang, Anqi
Tang, Chunping
Dien, Pham-Huu
Ye, Yang
author_sort Lin, Ligen
collection PubMed
description Two new N-oxide alkaloids with pyrrolo[1,2-α]azepine skeleton, namely isoneostemocochinine-N-oxide (1) and neostemocochinine-N-oxide (2), as well as three known alkaloids with pyrido[1,2-α]azepine skeletons, were isolated and identified from the roots of Stemona cochinchinensis (Stemonaceae). The structures of these compounds were elucidated by 1D- and 2D-NMR spectra and other spectroscopic studies. Additionally, the (1)H- and (13)C-NMR characteristic of N-oxide Stemona alkaloids was summarized. Stemokerrin showed potent anti-tussive activity on citric acid-induced guinea pig model.
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spelling pubmed-62713672018-12-28 Two New N-Oxide Alkaloids from Stemona cochinchinensis Lin, Ligen Bao, Han Wang, Anqi Tang, Chunping Dien, Pham-Huu Ye, Yang Molecules Article Two new N-oxide alkaloids with pyrrolo[1,2-α]azepine skeleton, namely isoneostemocochinine-N-oxide (1) and neostemocochinine-N-oxide (2), as well as three known alkaloids with pyrido[1,2-α]azepine skeletons, were isolated and identified from the roots of Stemona cochinchinensis (Stemonaceae). The structures of these compounds were elucidated by 1D- and 2D-NMR spectra and other spectroscopic studies. Additionally, the (1)H- and (13)C-NMR characteristic of N-oxide Stemona alkaloids was summarized. Stemokerrin showed potent anti-tussive activity on citric acid-induced guinea pig model. MDPI 2014-12-03 /pmc/articles/PMC6271367/ /pubmed/25479189 http://dx.doi.org/10.3390/molecules191220257 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Ligen
Bao, Han
Wang, Anqi
Tang, Chunping
Dien, Pham-Huu
Ye, Yang
Two New N-Oxide Alkaloids from Stemona cochinchinensis
title Two New N-Oxide Alkaloids from Stemona cochinchinensis
title_full Two New N-Oxide Alkaloids from Stemona cochinchinensis
title_fullStr Two New N-Oxide Alkaloids from Stemona cochinchinensis
title_full_unstemmed Two New N-Oxide Alkaloids from Stemona cochinchinensis
title_short Two New N-Oxide Alkaloids from Stemona cochinchinensis
title_sort two new n-oxide alkaloids from stemona cochinchinensis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271367/
https://www.ncbi.nlm.nih.gov/pubmed/25479189
http://dx.doi.org/10.3390/molecules191220257
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AT wanganqi twonewnoxidealkaloidsfromstemonacochinchinensis
AT tangchunping twonewnoxidealkaloidsfromstemonacochinchinensis
AT dienphamhuu twonewnoxidealkaloidsfromstemonacochinchinensis
AT yeyang twonewnoxidealkaloidsfromstemonacochinchinensis

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