Intramolecular Azide to Alkene Cycloadditions for the Construction of Pyrrolobenzodiazepines and Azetidino-Benzodiazepines

The coupling of proline- and azetidinone-substituted alkenes to 2-azidobenzoic and 2-azidobenzenesulfonic acid gives precursors that undergo intramolecular azide to alkene 1,3-dipolar cycloadditions to give imine-, triazoline- or aziridine-containing pyrrolo[1,4]benzodiazepines (PBDs), pyrrolo[1,2,5...

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Detalles Bibliográficos
Autores principales: Hemming, Karl, Chambers, Christopher S., Jamshaid, Faisal, O’Gorman, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271382/
https://www.ncbi.nlm.nih.gov/pubmed/25329868
http://dx.doi.org/10.3390/molecules191016737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271382/
https://www.ncbi.nlm.nih.gov/pubmed/25329868
http://dx.doi.org/10.3390/molecules191016737

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