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Synthesis and Biological Activities of Some New (N(α)-Dinicotinoyl)-bis-l-Leucyl Linear and Macrocyclic Peptides
A series of linear and macrocyclic peptides 3–12 were synthesized using 3,5-pyridinedicarboxylic acid (1) as starting material and screened for their antimicrobial, anti-inflammatory and anticancer activities. Bis-ester 3 was prepared from 1 and l-leucine methyl ester. Hydrazinolysis and hydrolysis...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271395/ https://www.ncbi.nlm.nih.gov/pubmed/25061721 http://dx.doi.org/10.3390/molecules190810698 |