Synthesis with Perfect Atom Economy: Generation of Furan Derivatives by 1,3-Dipolar Cycloaddition of Acetylenedicarboxylates at Cyclooctynes

Cyclooctyne and cycloocten-5-yne undergo, at room temperature, a 1,3-dipolar cycloaddition with dialkyl acetylenedicarboxylates 1a,b to generate furan-derived short-lived intermediates 2, which can be trapped by two additional equivalents of 1a,b or alternatively by methanol, phenol, water or aldehy...

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Detalles Bibliográficos
Autores principales: Banert, Klaus, Bochmann, Sandra, Ihle, Andreas, Plefka, Oliver, Taubert, Florian, Walther, Tina, Korb, Marcus, Rüffer, Tobias, Lang, Heinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271402/
https://www.ncbi.nlm.nih.gov/pubmed/25197937
http://dx.doi.org/10.3390/molecules190914022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271402/
https://www.ncbi.nlm.nih.gov/pubmed/25197937
http://dx.doi.org/10.3390/molecules190914022

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