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The Synergistic Biologic Activity of Oleanolic and Ursolic Acids in Complex with Hydroxypropyl-γ-Cyclodextrin
Oleanolic and ursolic acids are natural triterpenic compounds with pentacyclic cholesterol-like structures which gives them very low water solubility, a significant disadvantage in terms of bioavailability. We previously reported the synthesis of inclusion complexes between these acids and cyclodext...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271422/ https://www.ncbi.nlm.nih.gov/pubmed/24747649 http://dx.doi.org/10.3390/molecules19044924 |
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author | Soica, Codruţa Oprean, Camelia Borcan, Florin Danciu, Corina Trandafirescu, Cristina Coricovac, Dorina Crăiniceanu, Zorin Dehelean, Cristina Adriana Munteanu, Melania |
author_facet | Soica, Codruţa Oprean, Camelia Borcan, Florin Danciu, Corina Trandafirescu, Cristina Coricovac, Dorina Crăiniceanu, Zorin Dehelean, Cristina Adriana Munteanu, Melania |
author_sort | Soica, Codruţa |
collection | PubMed |
description | Oleanolic and ursolic acids are natural triterpenic compounds with pentacyclic cholesterol-like structures which gives them very low water solubility, a significant disadvantage in terms of bioavailability. We previously reported the synthesis of inclusion complexes between these acids and cyclodextrins, as well as their in vivo evaluation on chemically induced skin cancer experimental models. In this study the synergistic activity of the acid mixture included inside hydroxypropyl-gamma-cyclodextrin (HPGCD) was monitored using in vitro tests and in vivo skin cancer models. The coefficient of drug interaction (CDI) was used to characterize the interactions as synergism, additivity or antagonism. Our results revealed an increased antitumor activity for the mixture of the two triterpenic acids, both single and in complex with cyclodextrin, thus proving their complementary biologic activities. |
format | Online Article Text |
id | pubmed-6271422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62714222019-01-02 The Synergistic Biologic Activity of Oleanolic and Ursolic Acids in Complex with Hydroxypropyl-γ-Cyclodextrin Soica, Codruţa Oprean, Camelia Borcan, Florin Danciu, Corina Trandafirescu, Cristina Coricovac, Dorina Crăiniceanu, Zorin Dehelean, Cristina Adriana Munteanu, Melania Molecules Article Oleanolic and ursolic acids are natural triterpenic compounds with pentacyclic cholesterol-like structures which gives them very low water solubility, a significant disadvantage in terms of bioavailability. We previously reported the synthesis of inclusion complexes between these acids and cyclodextrins, as well as their in vivo evaluation on chemically induced skin cancer experimental models. In this study the synergistic activity of the acid mixture included inside hydroxypropyl-gamma-cyclodextrin (HPGCD) was monitored using in vitro tests and in vivo skin cancer models. The coefficient of drug interaction (CDI) was used to characterize the interactions as synergism, additivity or antagonism. Our results revealed an increased antitumor activity for the mixture of the two triterpenic acids, both single and in complex with cyclodextrin, thus proving their complementary biologic activities. MDPI 2014-04-17 /pmc/articles/PMC6271422/ /pubmed/24747649 http://dx.doi.org/10.3390/molecules19044924 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Soica, Codruţa Oprean, Camelia Borcan, Florin Danciu, Corina Trandafirescu, Cristina Coricovac, Dorina Crăiniceanu, Zorin Dehelean, Cristina Adriana Munteanu, Melania The Synergistic Biologic Activity of Oleanolic and Ursolic Acids in Complex with Hydroxypropyl-γ-Cyclodextrin |
title | The Synergistic Biologic Activity of Oleanolic and Ursolic Acids in Complex with Hydroxypropyl-γ-Cyclodextrin |
title_full | The Synergistic Biologic Activity of Oleanolic and Ursolic Acids in Complex with Hydroxypropyl-γ-Cyclodextrin |
title_fullStr | The Synergistic Biologic Activity of Oleanolic and Ursolic Acids in Complex with Hydroxypropyl-γ-Cyclodextrin |
title_full_unstemmed | The Synergistic Biologic Activity of Oleanolic and Ursolic Acids in Complex with Hydroxypropyl-γ-Cyclodextrin |
title_short | The Synergistic Biologic Activity of Oleanolic and Ursolic Acids in Complex with Hydroxypropyl-γ-Cyclodextrin |
title_sort | synergistic biologic activity of oleanolic and ursolic acids in complex with hydroxypropyl-γ-cyclodextrin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271422/ https://www.ncbi.nlm.nih.gov/pubmed/24747649 http://dx.doi.org/10.3390/molecules19044924 |
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