Cargando…

The Synergistic Biologic Activity of Oleanolic and Ursolic Acids in Complex with Hydroxypropyl-γ-Cyclodextrin

Oleanolic and ursolic acids are natural triterpenic compounds with pentacyclic cholesterol-like structures which gives them very low water solubility, a significant disadvantage in terms of bioavailability. We previously reported the synthesis of inclusion complexes between these acids and cyclodext...

Descripción completa

Detalles Bibliográficos
Autores principales:	Soica, Codruţa, Oprean, Camelia, Borcan, Florin, Danciu, Corina, Trandafirescu, Cristina, Coricovac, Dorina, Crăiniceanu, Zorin, Dehelean, Cristina Adriana, Munteanu, Melania
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271422/ https://www.ncbi.nlm.nih.gov/pubmed/24747649 http://dx.doi.org/10.3390/molecules19044924

Ejemplares similares

Effects of ursolic and oleanolic on SK-MEL-2 melanoma cells: In vitro and in vivo assays
por: Caunii, Angela, et al.
Publicado: (2017)

Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells
por: Soica, Codruta, et al.
Publicado: (2014)

Changes in the anti-inflammatory activity of soy isoflavonoid genistein versus genistein incorporated in two types of cyclodextrin derivatives
por: Danciu, CorinaTiulea, et al.
Publicado: (2012)

Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation
por: Danciu, Corina, et al.
Publicado: (2015)

Solid Polymeric Nanoparticles of Albendazole: Synthesis, Physico-Chemical Characterization and Biological Activity
por: Racoviceanu, Roxana, et al.
Publicado: (2020)

Genistein in 1:1 Inclusion Complexes with Ramified Cyclodextrins: Theoretical, Physicochemical and Biological Evaluation
por: Danciu, Corina, et al.
Publicado: (2014)

Evaluation of phenolic profile, antioxidant and anticancer potential of two main representants of Zingiberaceae family against B164A5 murine melanoma cells
por: Danciu, Corina, et al.
Publicado: (2015)

Synthesis and preliminary in vivo evaluations of polyurethane microstructures for transdermal drug delivery
por: Borcan, Florin, et al.
Publicado: (2012)

Melissa officinalis L. Aqueous Extract Exerts Antioxidant and Antiangiogenic Effects and Improves Physiological Skin Parameters
por: Sipos, Simona, et al.
Publicado: (2021)

In Vitro Assessment of the Cytotoxic and Antiproliferative Profile of Natural Preparations Containing Bergamot, Orange and Clove Essential Oils
por: Alexa, Vlad Tiberiu, et al.
Publicado: (2022)

Mechanistic investigations of antitumor activity of a Rhodamine B-oleanolic acid derivative bioconjugate
por: Macașoi, Ioana, et al.
Publicado: (2020)

Mechanistic investigations of antitumor activity of a Rhodamine B-oleanolic acid derivative bioconjugate
por: Macașoi, Ioana, et al.
Publicado: (2021)

Betulin Complex in γ-Cyclodextrin Derivatives: Properties and Antineoplasic Activities in In Vitro and In Vivo Tumor Models
por: Şoica, Codruta, et al.
Publicado: (2012)

Evaluation and differentiation of the Betulaceae birch bark species and their bioactive triterpene content using analytical FT-vibrational spectroscopy and GC-MS
por: Cîntă-Pînzaru, Simona, et al.
Publicado: (2012)

A characterization of four B16 murine melanoma cell sublines molecular fingerprint and proliferation behavior
por: Danciu, Corina, et al.
Publicado: (2013)

The Hydractinia echinata Test-System. III: Structure-Toxicity Relationship Study of Some Azo-, Azo-Anilide, and Diazonium Salt Derivatives
por: Chicu, Sergiu Adrian, et al.
Publicado: (2014)

Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer
por: Mioc, Marius, et al.
Publicado: (2018)

Germinated and Ungerminated Seeds Extract from Two Lupinus Species: Biological Compounds Characterization and In Vitro and In Vivo Evaluations
por: Andor, Bogdan, et al.
Publicado: (2016)

Lemon Balm Extracts Prevent Breast Cancer Progression In Vitro and In Ovo on Chorioallantoic Membrane Assay
por: Ghiulai, Roxana, et al.
Publicado: (2020)

A Study on the Behavior of a Polyurethane Drug Carrier in Various pH Media
por: Borcan, Florin, et al.
Publicado: (2020)

Botanical Therapeutics: Phytochemical Screening and Biological Assessment of Chamomile, Parsley and Celery Extracts against A375 Human Melanoma and Dendritic Cells
por: Danciu, Corina, et al.
Publicado: (2018)

Antibiotics: Conventional Therapy and Natural Compounds with Antibacterial Activity—A Pharmaco-Toxicological Screening
por: Pancu, Daniel Florin, et al.
Publicado: (2021)

Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy
por: Dehelean, Cristina Adriana, et al.
Publicado: (2021)

The Role of Cyclodextrins in the Design and Development of Triterpene-Based Therapeutic Agents
por: Prodea, Alexandra, et al.
Publicado: (2022)

The Cytotoxic Effects of Betulin-Conjugated Gold Nanoparticles as Stable Formulations in Normal and Melanoma Cells
por: Mioc, Marius, et al.
Publicado: (2018)

Antimicrobial Activity of Oleanolic and Ursolic Acids: An Update
por: Jesus, Jéssica A., et al.
Publicado: (2015)

Design and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of Acyclovir
por: Borcan, Florin, et al.
Publicado: (2020)

Phytochemical Characterization and Evaluation of the Antimicrobial, Antiproliferative and Pro-Apoptotic Potential of Ephedra alata Decne. Hydroalcoholic Extract against the MCF-7 Breast Cancer Cell Line
por: Danciu, Corina, et al.
Publicado: (2018)

A Comprehensive Assessment of Apigenin as an Antiproliferative, Proapoptotic, Antiangiogenic and Immunomodulatory Phytocompound
por: Ghițu, Alexandra, et al.
Publicado: (2019)

Proniosomal Gel for Topical Delivery of Rutin: Preparation, Physicochemical Characterization and In Vitro Toxicological Profile Using 3D Reconstructed Human Epidermis Tissue and 2D Cells
por: Pinzaru, Iulia, et al.
Publicado: (2021)

Structural Investigation of Betulinic Acid Plasma Metabolites by Tandem Mass Spectrometry
por: Ghiulai, Roxana, et al.
Publicado: (2022)

High Efficacy on the Death of Breast Cancer Cells Using SPMHT with Magnetite Cyclodextrins Nanobioconjugates
por: Caizer, Costica, et al.
Publicado: (2023)

Enhancement of Platelet Aggregation by Ursolic Acid and Oleanolic Acid
por: Kim, Mikyung, et al.
Publicado: (2014)

Ursolic and Oleanolic Acids: Plant Metabolites with Neuroprotective Potential
por: Gudoityte, Evelina, et al.
Publicado: (2021)

Host-guest interaction of β-cyclodextrin with isomeric ursolic acid and oleanolic acid: physicochemical characterization and molecular modeling study
por: Huang, Yuan, et al.
Publicado: (2017)

SARS-CoV-2: Repurposed Drugs and Novel Therapeutic Approaches—Insights into Chemical Structure—Biological Activity and Toxicological Screening
por: Dehelean, Cristina Adriana, et al.
Publicado: (2020)

Cocrystal Formation of Betulinic Acid and Ascorbic Acid: Synthesis, Physico-Chemical Assessment, Antioxidant, and Antiproliferative Activity
por: Nicolov, Mirela, et al.
Publicado: (2019)

In Vitro Evaluation of the Antimicrobial Ability and Cytotoxicity on Two Melanoma Cell Lines of a Benzylamide Derivative of Maslinic Acid
por: Pavel, Ioana Zinuca, et al.
Publicado: (2016)

Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation
por: Dehelean, Cristina A, et al.
Publicado: (2012)

Ursolic and oleanolic acids as antimicrobial and immunomodulatory compounds for tuberculosis treatment
por: Jiménez-Arellanes, Adelina, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_muurkefgebomk24ukmb6lvjlt7