Cargando…

Design, Synthesis and Biological Evaluation of C(6)-Modified Celastrol Derivatives as Potential Antitumor Agents

New six C6-celastrol derivatives were designed, synthesized, and evaluated for their in vitro cytotoxic activities against nine human cancer cell lines (BGC-823, H4, Bel7402, H522, Colo 205, HepG2 and MDA-MB-468). The results showed that most of the compounds displayed potent inhibition against BGC8...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Kaiyong, Huang, Qingqing, Zeng, Jafeng, Wu, Guangming, Huang, Jinwen, Pan, Junfang, Lu, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271447/ https://www.ncbi.nlm.nih.gov/pubmed/25025148 http://dx.doi.org/10.3390/molecules190710177

Ejemplares similares

Synthesis and biological evaluation of celastrol derivatives as potent antitumor agents with STAT3 inhibition
por: Xu, Shaohua, et al.
Publicado: (2021)

Synthesis and characterisation of celastrol derivatives as potential anticancer agents
por: Zhang, Hong-Jian, et al.
Publicado: (2017)

Design, Synthesis, and Biological Evaluation of Novel Biotinylated Podophyllotoxin Derivatives as Potential Antitumor Agents
por: Zi, Cheng-Ting, et al.
Publicado: (2019)

Synthesis and biological evaluation of dehydroabietic acid-pyrimidine hybrids as antitumor agents
por: Huang, Lin, et al.
Publicado: (2020)

Design, synthesis, and biological evaluation of biotinylated colchicine derivatives as potential antitumor agents
por: Wang, Chao, et al.
Publicado: (2021)

Design, Synthesis and Biological Evaluation of Novel 4-Substituted Coumarin Derivatives as Antitumor Agents
por: An, Ran, et al.
Publicado: (2018)

Antitumor activity of celastrol nanoparticles in a xenograft retinoblastoma tumor model
por: Li, Zhanrong, et al.
Publicado: (2012)

Systematic identification of Celastrol-binding proteins reveals that Shoc2 is inhibited by Celastrol
por: Xiao-pei, Huang, et al.
Publicado: (2018)

Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents
por: Tang, Haosha, et al.
Publicado: (2019)

Synthesis and anticancer properties of celastrol derivatives involved in the inhibition of VEGF
por: Song, Mingxia, et al.
Publicado: (2023)

Novel antitumor DNA monoalkylating agents: Synthesis and biological evaluation
por: Brito, Ana F, et al.
Publicado: (2010)

Synthesis and Biological Evaluation of Phaeosphaeride A Derivatives as Antitumor Agents
por: Abzianidze, Victoria, et al.
Publicado: (2018)

Synthesis of Novel Tryptamine Derivatives and Their Biological Activity as Antitumor Agents
por: Simonetti, Giorgia, et al.
Publicado: (2021)

Synthesis and Biological Evaluation of Novel Allobetulon/Allobetulin–Nucleoside Conjugates as AntitumorAgents
por: Wang, Yanli, et al.
Publicado: (2022)

Synthesis, Biological Evaluation, DNA Binding, and Molecular Docking of Hybrid 4,6-Dihydrazone Pyrimidine Derivatives as Antitumor Agents
por: Lan, Hairong, et al.
Publicado: (2022)

Design, Synthesis, and Biological Evaluation of Novel Nitrogen Heterocycle-Containing Ursolic Acid Analogs as Antitumor Agents
por: Wang, Wenzhi, et al.
Publicado: (2019)

Celastrol: A Promising Agent Fighting against Cardiovascular Diseases
por: Li, Zhexi, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents
por: Xie, Yong-Mei, et al.
Publicado: (2011)

Synthesis and Biological Evaluation of Novel Dehydroabietic Acid Derivatives Conjugated with Acyl-Thiourea Peptide Moiety as Antitumor Agents
por: Jin, Le, et al.
Publicado: (2015)

Synthesis and Biological Evaluation of Novel N-Methyl-picolinamide-4-thiol Derivatives as Potential Antitumor Agents
por: Huang, Ting-Ting, et al.
Publicado: (2012)

The Synthesis and Biological Evaluation of Aloe-Emodin-Coumarin Hybrids as Potential Antitumor Agents
por: Shang, Hai, et al.
Publicado: (2022)

Design, Synthesis and In Vitro Investigation of Novel Basic Celastrol Carboxamides as Bio-Inspired Leishmanicidal Agents Endowed with Inhibitory Activity against Leishmania Hsp90
por: Bassanini, Ivan, et al.
Publicado: (2021)

Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates
por: Bi, Yi, et al.
Publicado: (2012)

Design, synthesis and biological evaluation of VEGFR-2/HDAC dual inhibitors as multitargeted antitumor agents based on fruquintinib and vorinostat
por: Gao, Yali, et al.
Publicado: (2023)

Regulating mitochondrial homeostasis and inhibiting inflammatory responses through Celastrol
por: Tao, Zhenyu, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of Novel 4-(4-Formamidophenylamino)-N-methylpicolinamide Derivatives as Potential Antitumor Agents
por: Meng, Nana, et al.
Publicado: (2021)

Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids
por: Wang, Huabo, et al.
Publicado: (2015)

Design, synthesis and evaluation of novel 2-oxoindoline-based acetohydrazides as antitumor agents
por: Dung, Do T. M., et al.
Publicado: (2022)

Celastrol elicits antitumor effects by inhibiting the STAT3 pathway through ROS accumulation in non-small cell lung cancer
por: Zhao, Zhucheng, et al.
Publicado: (2022)

Design, Synthesis, Mechanisms of Action, and Toxicity of Novel 20(S)-Sulfonylamidine Derivatives of Camptothecin as Potent Antitumor Agents
por: Wang, Mei-Juan, et al.
Publicado: (2014)

Synthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents
por: El-serwy, Walaa S., et al.
Publicado: (2016)

Synthesis and Biological Evaluation of Novel 1-Alkyl-tryptophan Analogs as Potential Antitumor Agents
por: Sun, Ting, et al.
Publicado: (2009)

Design, Synthesis, and Biological Evaluation of N14-Amino Acid-Substituted Tetrandrine Derivatives as Potential Antitumor Agents against Human Colorectal Cancer
por: Wang, Yu-Chan, et al.
Publicado: (2022)

Correction: Systematic identification of celastrol-binding proteins reveals that Shoc2 is inhibited by celastrol
Publicado: (2021)

The Potential Therapeutic Role of Celastrol in Patients With Heart Failure With Preserved Ejection Fraction
por: Ajmal, Maryam, et al.
Publicado: (2021)

Design and Synthesis of Molecular Hybrids of Sophora Alkaloids and Cinnamic Acids as Potential Antitumor Agents
por: Shang, Hai, et al.
Publicado: (2020)

Augmenting Antitumor Immune Responses with Epigenetic Modifying Agents
por: Héninger, Erika, et al.
Publicado: (2015)

Celastrol-conjugated chitosan oligosaccharide for the treatment of pancreatic cancer
por: Zeng, Xiaohu, et al.
Publicado: (2021)

Discovery of Hybrid Dual N-Acylhydrazone and Diaryl Urea Derivatives as Potent Antitumor Agents: Design, Synthesis and Cytotoxicity Evaluation
por: Zhai, Xin, et al.
Publicado: (2013)

PERK in POMC neurons connects celastrol with metabolism
por: He, Zhenyan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hnjogkepsi2qaivnn2cvieakv5