The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China

Four new anthraquinone derivatives 1–4 were obtained along with seven known compounds 5–11 from the extracts of the fungal strain Alternaria sp. XZSBG-1 which was isolated from the sediments of the carbonate saline lake in Bange, Tibet, China. Their structures were determined by spectroscopic method...

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Detalles Bibliográficos
Autores principales: Chen, Bin, Shen, Qiong, Zhu, Xun, Lin, Yongcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271467/
https://www.ncbi.nlm.nih.gov/pubmed/25317580
http://dx.doi.org/10.3390/molecules191016529
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author Chen, Bin
Shen, Qiong
Zhu, Xun
Lin, Yongcheng
author_facet Chen, Bin
Shen, Qiong
Zhu, Xun
Lin, Yongcheng
author_sort Chen, Bin
collection PubMed
description Four new anthraquinone derivatives 1–4 were obtained along with seven known compounds 5–11 from the extracts of the fungal strain Alternaria sp. XZSBG-1 which was isolated from the sediments of the carbonate saline lake in Bange, Tibet, China. Their structures were determined by spectroscopic methods, mainly by 2D NMR spectra. Compound 1 is a novel tetrahydroanthraquinone with an epoxy ether bond between C-4a and C-9a. In the primary bioassays, compound 3 (alterporriol T) exhibited inhibition of a-glucosidase with a IC(50) value 7.2 μM, and compound 9 showed good inhibitory activity against the HCT-116 and HeLa cell lines, with IC(50) values of 3.03 and 8.09 μM, respectively.
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spelling pubmed-62714672018-12-27 The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China Chen, Bin Shen, Qiong Zhu, Xun Lin, Yongcheng Molecules Article Four new anthraquinone derivatives 1–4 were obtained along with seven known compounds 5–11 from the extracts of the fungal strain Alternaria sp. XZSBG-1 which was isolated from the sediments of the carbonate saline lake in Bange, Tibet, China. Their structures were determined by spectroscopic methods, mainly by 2D NMR spectra. Compound 1 is a novel tetrahydroanthraquinone with an epoxy ether bond between C-4a and C-9a. In the primary bioassays, compound 3 (alterporriol T) exhibited inhibition of a-glucosidase with a IC(50) value 7.2 μM, and compound 9 showed good inhibitory activity against the HCT-116 and HeLa cell lines, with IC(50) values of 3.03 and 8.09 μM, respectively. MDPI 2014-10-14 /pmc/articles/PMC6271467/ /pubmed/25317580 http://dx.doi.org/10.3390/molecules191016529 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Bin
Shen, Qiong
Zhu, Xun
Lin, Yongcheng
The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China
title The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China
title_full The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China
title_fullStr The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China
title_full_unstemmed The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China
title_short The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China
title_sort anthraquinone derivatives from the fungus alternaria sp. xzsbg-1 from the saline lake in bange, tibet, china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271467/
https://www.ncbi.nlm.nih.gov/pubmed/25317580
http://dx.doi.org/10.3390/molecules191016529
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