Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds

Three new multiflorane-type triterpene esters, i.e. 7α-hydroxymultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (1), 7α-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (2), and 7β-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (3), were isolated from seeds of Cucurbita maxima, along with the kno...

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Detalles Bibliográficos
Autores principales: Kikuchi, Takashi, Ueda, Shinsuke, Kanazawa, Jokaku, Naoe, Hiroki, Yamada, Takeshi, Tanaka, Reiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271469/
https://www.ncbi.nlm.nih.gov/pubmed/24743937
http://dx.doi.org/10.3390/molecules19044802
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author Kikuchi, Takashi
Ueda, Shinsuke
Kanazawa, Jokaku
Naoe, Hiroki
Yamada, Takeshi
Tanaka, Reiko
author_facet Kikuchi, Takashi
Ueda, Shinsuke
Kanazawa, Jokaku
Naoe, Hiroki
Yamada, Takeshi
Tanaka, Reiko
author_sort Kikuchi, Takashi
collection PubMed
description Three new multiflorane-type triterpene esters, i.e. 7α-hydroxymultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (1), 7α-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (2), and 7β-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (3), were isolated from seeds of Cucurbita maxima, along with the known compound, multiflora-7,9(11)-diene-3α,29-diol 3,29-dibenzoate (4). Compound 1 exhibited melanogenesis inhibitory activities comparable with those of arbutin. In cytotoxicity assays, compounds 1 and 3 exhibited weak cytotoxicity, with IC(50) values of 34.5–93.7 μM against HL-60 and P388 cells.
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spelling pubmed-62714692019-01-02 Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds Kikuchi, Takashi Ueda, Shinsuke Kanazawa, Jokaku Naoe, Hiroki Yamada, Takeshi Tanaka, Reiko Molecules Article Three new multiflorane-type triterpene esters, i.e. 7α-hydroxymultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (1), 7α-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (2), and 7β-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (3), were isolated from seeds of Cucurbita maxima, along with the known compound, multiflora-7,9(11)-diene-3α,29-diol 3,29-dibenzoate (4). Compound 1 exhibited melanogenesis inhibitory activities comparable with those of arbutin. In cytotoxicity assays, compounds 1 and 3 exhibited weak cytotoxicity, with IC(50) values of 34.5–93.7 μM against HL-60 and P388 cells. MDPI 2014-04-16 /pmc/articles/PMC6271469/ /pubmed/24743937 http://dx.doi.org/10.3390/molecules19044802 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kikuchi, Takashi
Ueda, Shinsuke
Kanazawa, Jokaku
Naoe, Hiroki
Yamada, Takeshi
Tanaka, Reiko
Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds
title Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds
title_full Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds
title_fullStr Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds
title_full_unstemmed Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds
title_short Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds
title_sort three new triterpene esters from pumpkin (cucurbita maxima) seeds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271469/
https://www.ncbi.nlm.nih.gov/pubmed/24743937
http://dx.doi.org/10.3390/molecules19044802
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