New Biscoumarin Derivatives: Synthesis, Crystal Structure, Theoretical Study and Antibacterial Activity against Staphylococcus aureus

Five novel biscoumarins 1–5 were synthesized and characterized. In these compounds, two classical asymmetrical intramolecular O–H···O hydrogen bonds were used to stabilize the whole structures and the HB energies were performed with the density functional theory (DFT) [B3LYP/6-31G*] method. The five...

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Detalles Bibliográficos
Autores principales: Qu, Di, Li, Jing, Yang, Xiao-Hui, Zhang, Zi-Dan, Luo, Xiao-Xing, Li, Ming-Kai, Li, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271470/
https://www.ncbi.nlm.nih.gov/pubmed/25460310
http://dx.doi.org/10.3390/molecules191219868
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author Qu, Di
Li, Jing
Yang, Xiao-Hui
Zhang, Zi-Dan
Luo, Xiao-Xing
Li, Ming-Kai
Li, Xia
author_facet Qu, Di
Li, Jing
Yang, Xiao-Hui
Zhang, Zi-Dan
Luo, Xiao-Xing
Li, Ming-Kai
Li, Xia
author_sort Qu, Di
collection PubMed
description Five novel biscoumarins 1–5 were synthesized and characterized. In these compounds, two classical asymmetrical intramolecular O–H···O hydrogen bonds were used to stabilize the whole structures and the HB energies were performed with the density functional theory (DFT) [B3LYP/6-31G*] method. The five compounds were evaluated for their in vitro antibacterial activities against Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), and USA 300 (Los Angeles County clone, LAC) by the means of minimum inhibitory concentration and time-kill curves.
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spelling pubmed-62714702018-12-28 New Biscoumarin Derivatives: Synthesis, Crystal Structure, Theoretical Study and Antibacterial Activity against Staphylococcus aureus Qu, Di Li, Jing Yang, Xiao-Hui Zhang, Zi-Dan Luo, Xiao-Xing Li, Ming-Kai Li, Xia Molecules Article Five novel biscoumarins 1–5 were synthesized and characterized. In these compounds, two classical asymmetrical intramolecular O–H···O hydrogen bonds were used to stabilize the whole structures and the HB energies were performed with the density functional theory (DFT) [B3LYP/6-31G*] method. The five compounds were evaluated for their in vitro antibacterial activities against Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), and USA 300 (Los Angeles County clone, LAC) by the means of minimum inhibitory concentration and time-kill curves. MDPI 2014-11-28 /pmc/articles/PMC6271470/ /pubmed/25460310 http://dx.doi.org/10.3390/molecules191219868 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Qu, Di
Li, Jing
Yang, Xiao-Hui
Zhang, Zi-Dan
Luo, Xiao-Xing
Li, Ming-Kai
Li, Xia
New Biscoumarin Derivatives: Synthesis, Crystal Structure, Theoretical Study and Antibacterial Activity against Staphylococcus aureus
title New Biscoumarin Derivatives: Synthesis, Crystal Structure, Theoretical Study and Antibacterial Activity against Staphylococcus aureus
title_full New Biscoumarin Derivatives: Synthesis, Crystal Structure, Theoretical Study and Antibacterial Activity against Staphylococcus aureus
title_fullStr New Biscoumarin Derivatives: Synthesis, Crystal Structure, Theoretical Study and Antibacterial Activity against Staphylococcus aureus
title_full_unstemmed New Biscoumarin Derivatives: Synthesis, Crystal Structure, Theoretical Study and Antibacterial Activity against Staphylococcus aureus
title_short New Biscoumarin Derivatives: Synthesis, Crystal Structure, Theoretical Study and Antibacterial Activity against Staphylococcus aureus
title_sort new biscoumarin derivatives: synthesis, crystal structure, theoretical study and antibacterial activity against staphylococcus aureus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271470/
https://www.ncbi.nlm.nih.gov/pubmed/25460310
http://dx.doi.org/10.3390/molecules191219868
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