Batch and Continuous Flow Preparation of Hantzsch 1,4-Dihydropyridines under Microwave Heating and Simultaneous Real-time Monitoring by Raman Spectroscopy. An Exploratory Study

Dialkyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates have been prepared in a batch mode under conventional heating as well as under continuous flow conditions in the Miniflow 200SS, Sairem’s microwave-assisted batch and continuous flow equipment. Real-time monitoring of the reactions by Raman...

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Autores principales: Christiaens, Sylvain, Vantyghem, Xavier, Radoiu, Marilena, Vanden Eynde, Jean Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271481/
https://www.ncbi.nlm.nih.gov/pubmed/25010470
http://dx.doi.org/10.3390/molecules19079986
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author Christiaens, Sylvain
Vantyghem, Xavier
Radoiu, Marilena
Vanden Eynde, Jean Jacques
author_facet Christiaens, Sylvain
Vantyghem, Xavier
Radoiu, Marilena
Vanden Eynde, Jean Jacques
author_sort Christiaens, Sylvain
collection PubMed
description Dialkyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates have been prepared in a batch mode under conventional heating as well as under continuous flow conditions in the Miniflow 200SS, Sairem’s microwave-assisted batch and continuous flow equipment. Real-time monitoring of the reactions by Raman spectroscopy enabled to compare both heating modes and to determine (optimized) reaction times.
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spelling pubmed-62714812018-12-21 Batch and Continuous Flow Preparation of Hantzsch 1,4-Dihydropyridines under Microwave Heating and Simultaneous Real-time Monitoring by Raman Spectroscopy. An Exploratory Study Christiaens, Sylvain Vantyghem, Xavier Radoiu, Marilena Vanden Eynde, Jean Jacques Molecules Article Dialkyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates have been prepared in a batch mode under conventional heating as well as under continuous flow conditions in the Miniflow 200SS, Sairem’s microwave-assisted batch and continuous flow equipment. Real-time monitoring of the reactions by Raman spectroscopy enabled to compare both heating modes and to determine (optimized) reaction times. MDPI 2014-07-09 /pmc/articles/PMC6271481/ /pubmed/25010470 http://dx.doi.org/10.3390/molecules19079986 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Christiaens, Sylvain
Vantyghem, Xavier
Radoiu, Marilena
Vanden Eynde, Jean Jacques
Batch and Continuous Flow Preparation of Hantzsch 1,4-Dihydropyridines under Microwave Heating and Simultaneous Real-time Monitoring by Raman Spectroscopy. An Exploratory Study
title Batch and Continuous Flow Preparation of Hantzsch 1,4-Dihydropyridines under Microwave Heating and Simultaneous Real-time Monitoring by Raman Spectroscopy. An Exploratory Study
title_full Batch and Continuous Flow Preparation of Hantzsch 1,4-Dihydropyridines under Microwave Heating and Simultaneous Real-time Monitoring by Raman Spectroscopy. An Exploratory Study
title_fullStr Batch and Continuous Flow Preparation of Hantzsch 1,4-Dihydropyridines under Microwave Heating and Simultaneous Real-time Monitoring by Raman Spectroscopy. An Exploratory Study
title_full_unstemmed Batch and Continuous Flow Preparation of Hantzsch 1,4-Dihydropyridines under Microwave Heating and Simultaneous Real-time Monitoring by Raman Spectroscopy. An Exploratory Study
title_short Batch and Continuous Flow Preparation of Hantzsch 1,4-Dihydropyridines under Microwave Heating and Simultaneous Real-time Monitoring by Raman Spectroscopy. An Exploratory Study
title_sort batch and continuous flow preparation of hantzsch 1,4-dihydropyridines under microwave heating and simultaneous real-time monitoring by raman spectroscopy. an exploratory study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271481/
https://www.ncbi.nlm.nih.gov/pubmed/25010470
http://dx.doi.org/10.3390/molecules19079986
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