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Angelica sinensis Improves Exercise Performance and Protects against Physical Fatigue in Trained Mice

Angelica sinensis (AS) is a well-known medicinal herb and food material with antioxidative and multifunctional pharmacological activities. However, we lack evidence of the effect of AS on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effect of AS on ergogen...

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Autores principales: Yeh, Tzu-Shao, Huang, Chi-Chang, Chuang, Hsiao-Li, Hsu, Mei-Chich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271504/
https://www.ncbi.nlm.nih.gov/pubmed/24691065
http://dx.doi.org/10.3390/molecules19043926
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author Yeh, Tzu-Shao
Huang, Chi-Chang
Chuang, Hsiao-Li
Hsu, Mei-Chich
author_facet Yeh, Tzu-Shao
Huang, Chi-Chang
Chuang, Hsiao-Li
Hsu, Mei-Chich
author_sort Yeh, Tzu-Shao
collection PubMed
description Angelica sinensis (AS) is a well-known medicinal herb and food material with antioxidative and multifunctional pharmacological activities. However, we lack evidence of the effect of AS on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effect of AS on ergogenic and anti-fatigue functions after physiological challenge. Male ICR strain mice were randomly assigned to four groups (n = 10 per group) for treatment: (1) sedentary control and vehicle treatment (vehicle control); (2) exercise training with vehicle treatment (exercise control); (3) exercise training with AS treatment at 0.41 g/kg/day (Ex-AS1); and (4) 2.05 g/kg/day (Ex-AS5); both the vehicle and AS were orally administered for 6 weeks. Exercise performance and anti-fatigue function were evaluated by forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, and creatine kinase (CK) after a 15-min swimming exercise. Trend analysis revealed that AS treatments significantly increased endurance swimming time and blood glucose level, and decreased serum lactate, ammonia and CK levels. Liver and muscle glycogen contents were higher for Ex-AS1 and Ex-AS5 groups than the exercise control. Therefore, AS supplementation improved exercise performance and had anti-fatigue properties in mice and may be an effective ergogenic aid in exercise training.
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spelling pubmed-62715042019-01-02 Angelica sinensis Improves Exercise Performance and Protects against Physical Fatigue in Trained Mice Yeh, Tzu-Shao Huang, Chi-Chang Chuang, Hsiao-Li Hsu, Mei-Chich Molecules Article Angelica sinensis (AS) is a well-known medicinal herb and food material with antioxidative and multifunctional pharmacological activities. However, we lack evidence of the effect of AS on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effect of AS on ergogenic and anti-fatigue functions after physiological challenge. Male ICR strain mice were randomly assigned to four groups (n = 10 per group) for treatment: (1) sedentary control and vehicle treatment (vehicle control); (2) exercise training with vehicle treatment (exercise control); (3) exercise training with AS treatment at 0.41 g/kg/day (Ex-AS1); and (4) 2.05 g/kg/day (Ex-AS5); both the vehicle and AS were orally administered for 6 weeks. Exercise performance and anti-fatigue function were evaluated by forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, and creatine kinase (CK) after a 15-min swimming exercise. Trend analysis revealed that AS treatments significantly increased endurance swimming time and blood glucose level, and decreased serum lactate, ammonia and CK levels. Liver and muscle glycogen contents were higher for Ex-AS1 and Ex-AS5 groups than the exercise control. Therefore, AS supplementation improved exercise performance and had anti-fatigue properties in mice and may be an effective ergogenic aid in exercise training. MDPI 2014-03-31 /pmc/articles/PMC6271504/ /pubmed/24691065 http://dx.doi.org/10.3390/molecules19043926 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yeh, Tzu-Shao
Huang, Chi-Chang
Chuang, Hsiao-Li
Hsu, Mei-Chich
Angelica sinensis Improves Exercise Performance and Protects against Physical Fatigue in Trained Mice
title Angelica sinensis Improves Exercise Performance and Protects against Physical Fatigue in Trained Mice
title_full Angelica sinensis Improves Exercise Performance and Protects against Physical Fatigue in Trained Mice
title_fullStr Angelica sinensis Improves Exercise Performance and Protects against Physical Fatigue in Trained Mice
title_full_unstemmed Angelica sinensis Improves Exercise Performance and Protects against Physical Fatigue in Trained Mice
title_short Angelica sinensis Improves Exercise Performance and Protects against Physical Fatigue in Trained Mice
title_sort angelica sinensis improves exercise performance and protects against physical fatigue in trained mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271504/
https://www.ncbi.nlm.nih.gov/pubmed/24691065
http://dx.doi.org/10.3390/molecules19043926
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