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Two New Coumarins from Talaromyces flavus

Two new coumarins, talacoumarins A (1) and B (2), were isolated from the ethyl acetate extract of the wetland soil-derived fungus Talaromyces flavus BYD07-13. Their structures were elucidated by spectroscopic data (NMR, MS) analyses. The absolute configuration of C-12 in 1 was assigned using the mod...

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Autores principales: He, Jun-Wei, Qin, Da-Peng, Gao, Hao, Kuang, Run-Qiao, Yu, Yang, Liu, Xing-Zhong, Yao, Xin-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271517/
https://www.ncbi.nlm.nih.gov/pubmed/25514227
http://dx.doi.org/10.3390/molecules191220880
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author He, Jun-Wei
Qin, Da-Peng
Gao, Hao
Kuang, Run-Qiao
Yu, Yang
Liu, Xing-Zhong
Yao, Xin-Sheng
author_facet He, Jun-Wei
Qin, Da-Peng
Gao, Hao
Kuang, Run-Qiao
Yu, Yang
Liu, Xing-Zhong
Yao, Xin-Sheng
author_sort He, Jun-Wei
collection PubMed
description Two new coumarins, talacoumarins A (1) and B (2), were isolated from the ethyl acetate extract of the wetland soil-derived fungus Talaromyces flavus BYD07-13. Their structures were elucidated by spectroscopic data (NMR, MS) analyses. The absolute configuration of C-12 in 1 was assigned using the modified Mosher’s method, whereas that of C-12 in 2 was deduced via the circular dichroism data of its corresponding [Rh(2)(OCOCF(3))(4)] complex. Compounds 1 and 2 were evaluated for their anti-Aβ(42) aggregation, cytotoxic, and antimicrobial activities. The results showed that the two compounds had moderate anti-Aβ(42) aggregation activity, and this is the first report on the Aβ(42) inhibitory aggregation activity of coumarins.
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spelling pubmed-62715172018-12-28 Two New Coumarins from Talaromyces flavus He, Jun-Wei Qin, Da-Peng Gao, Hao Kuang, Run-Qiao Yu, Yang Liu, Xing-Zhong Yao, Xin-Sheng Molecules Article Two new coumarins, talacoumarins A (1) and B (2), were isolated from the ethyl acetate extract of the wetland soil-derived fungus Talaromyces flavus BYD07-13. Their structures were elucidated by spectroscopic data (NMR, MS) analyses. The absolute configuration of C-12 in 1 was assigned using the modified Mosher’s method, whereas that of C-12 in 2 was deduced via the circular dichroism data of its corresponding [Rh(2)(OCOCF(3))(4)] complex. Compounds 1 and 2 were evaluated for their anti-Aβ(42) aggregation, cytotoxic, and antimicrobial activities. The results showed that the two compounds had moderate anti-Aβ(42) aggregation activity, and this is the first report on the Aβ(42) inhibitory aggregation activity of coumarins. MDPI 2014-12-12 /pmc/articles/PMC6271517/ /pubmed/25514227 http://dx.doi.org/10.3390/molecules191220880 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
He, Jun-Wei
Qin, Da-Peng
Gao, Hao
Kuang, Run-Qiao
Yu, Yang
Liu, Xing-Zhong
Yao, Xin-Sheng
Two New Coumarins from Talaromyces flavus
title Two New Coumarins from Talaromyces flavus
title_full Two New Coumarins from Talaromyces flavus
title_fullStr Two New Coumarins from Talaromyces flavus
title_full_unstemmed Two New Coumarins from Talaromyces flavus
title_short Two New Coumarins from Talaromyces flavus
title_sort two new coumarins from talaromyces flavus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271517/
https://www.ncbi.nlm.nih.gov/pubmed/25514227
http://dx.doi.org/10.3390/molecules191220880
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