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Two New Coumarins from Talaromyces flavus
Two new coumarins, talacoumarins A (1) and B (2), were isolated from the ethyl acetate extract of the wetland soil-derived fungus Talaromyces flavus BYD07-13. Their structures were elucidated by spectroscopic data (NMR, MS) analyses. The absolute configuration of C-12 in 1 was assigned using the mod...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271517/ https://www.ncbi.nlm.nih.gov/pubmed/25514227 http://dx.doi.org/10.3390/molecules191220880 |
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author | He, Jun-Wei Qin, Da-Peng Gao, Hao Kuang, Run-Qiao Yu, Yang Liu, Xing-Zhong Yao, Xin-Sheng |
author_facet | He, Jun-Wei Qin, Da-Peng Gao, Hao Kuang, Run-Qiao Yu, Yang Liu, Xing-Zhong Yao, Xin-Sheng |
author_sort | He, Jun-Wei |
collection | PubMed |
description | Two new coumarins, talacoumarins A (1) and B (2), were isolated from the ethyl acetate extract of the wetland soil-derived fungus Talaromyces flavus BYD07-13. Their structures were elucidated by spectroscopic data (NMR, MS) analyses. The absolute configuration of C-12 in 1 was assigned using the modified Mosher’s method, whereas that of C-12 in 2 was deduced via the circular dichroism data of its corresponding [Rh(2)(OCOCF(3))(4)] complex. Compounds 1 and 2 were evaluated for their anti-Aβ(42) aggregation, cytotoxic, and antimicrobial activities. The results showed that the two compounds had moderate anti-Aβ(42) aggregation activity, and this is the first report on the Aβ(42) inhibitory aggregation activity of coumarins. |
format | Online Article Text |
id | pubmed-6271517 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62715172018-12-28 Two New Coumarins from Talaromyces flavus He, Jun-Wei Qin, Da-Peng Gao, Hao Kuang, Run-Qiao Yu, Yang Liu, Xing-Zhong Yao, Xin-Sheng Molecules Article Two new coumarins, talacoumarins A (1) and B (2), were isolated from the ethyl acetate extract of the wetland soil-derived fungus Talaromyces flavus BYD07-13. Their structures were elucidated by spectroscopic data (NMR, MS) analyses. The absolute configuration of C-12 in 1 was assigned using the modified Mosher’s method, whereas that of C-12 in 2 was deduced via the circular dichroism data of its corresponding [Rh(2)(OCOCF(3))(4)] complex. Compounds 1 and 2 were evaluated for their anti-Aβ(42) aggregation, cytotoxic, and antimicrobial activities. The results showed that the two compounds had moderate anti-Aβ(42) aggregation activity, and this is the first report on the Aβ(42) inhibitory aggregation activity of coumarins. MDPI 2014-12-12 /pmc/articles/PMC6271517/ /pubmed/25514227 http://dx.doi.org/10.3390/molecules191220880 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article He, Jun-Wei Qin, Da-Peng Gao, Hao Kuang, Run-Qiao Yu, Yang Liu, Xing-Zhong Yao, Xin-Sheng Two New Coumarins from Talaromyces flavus |
title | Two New Coumarins from Talaromyces flavus |
title_full | Two New Coumarins from Talaromyces flavus |
title_fullStr | Two New Coumarins from Talaromyces flavus |
title_full_unstemmed | Two New Coumarins from Talaromyces flavus |
title_short | Two New Coumarins from Talaromyces flavus |
title_sort | two new coumarins from talaromyces flavus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271517/ https://www.ncbi.nlm.nih.gov/pubmed/25514227 http://dx.doi.org/10.3390/molecules191220880 |
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