Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities

A series of 2,4-disubstituted quinazoline derivatives were designed and synthesized. The biological results showed that most of quinazoline derivatives exhibited potent antiproliferative activities against a panel of three tumor cell lines and a good inhibitory effect against the adhesion and migrat...

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Detalles Bibliográficos
Autores principales: Yu, Guangjin, Li, Zeng, Tang, Liang, Xiong, Qiru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271559/
https://www.ncbi.nlm.nih.gov/pubmed/24972275
http://dx.doi.org/10.3390/molecules19078916
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author Yu, Guangjin
Li, Zeng
Tang, Liang
Xiong, Qiru
author_facet Yu, Guangjin
Li, Zeng
Tang, Liang
Xiong, Qiru
author_sort Yu, Guangjin
collection PubMed
description A series of 2,4-disubstituted quinazoline derivatives were designed and synthesized. The biological results showed that most of quinazoline derivatives exhibited potent antiproliferative activities against a panel of three tumor cell lines and a good inhibitory effect against the adhesion and migration of human umbilical vein endothelial cells (HUVECs). Among these compounds, 11d was the most potent agent, that alsoexhibited the highest anti-angiogenesis activities in the chick embryo chorioallantoic membrane (CAM) assay.
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spelling pubmed-62715592018-12-21 Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities Yu, Guangjin Li, Zeng Tang, Liang Xiong, Qiru Molecules Article A series of 2,4-disubstituted quinazoline derivatives were designed and synthesized. The biological results showed that most of quinazoline derivatives exhibited potent antiproliferative activities against a panel of three tumor cell lines and a good inhibitory effect against the adhesion and migration of human umbilical vein endothelial cells (HUVECs). Among these compounds, 11d was the most potent agent, that alsoexhibited the highest anti-angiogenesis activities in the chick embryo chorioallantoic membrane (CAM) assay. MDPI 2014-06-26 /pmc/articles/PMC6271559/ /pubmed/24972275 http://dx.doi.org/10.3390/molecules19078916 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yu, Guangjin
Li, Zeng
Tang, Liang
Xiong, Qiru
Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities
title Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities
title_full Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities
title_fullStr Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities
title_full_unstemmed Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities
title_short Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities
title_sort synthesis and evaluation of 2,4-disubstituted quinazoline derivatives with potent anti-angiogenesis activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271559/
https://www.ncbi.nlm.nih.gov/pubmed/24972275
http://dx.doi.org/10.3390/molecules19078916
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AT lizeng synthesisandevaluationof24disubstitutedquinazolinederivativeswithpotentantiangiogenesisactivities
AT tangliang synthesisandevaluationof24disubstitutedquinazolinederivativeswithpotentantiangiogenesisactivities
AT xiongqiru synthesisandevaluationof24disubstitutedquinazolinederivativeswithpotentantiangiogenesisactivities

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