Cargando…

Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities

A series of 2,4-disubstituted quinazoline derivatives were designed and synthesized. The biological results showed that most of quinazoline derivatives exhibited potent antiproliferative activities against a panel of three tumor cell lines and a good inhibitory effect against the adhesion and migrat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Guangjin, Li, Zeng, Tang, Liang, Xiong, Qiru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271559/ https://www.ncbi.nlm.nih.gov/pubmed/24972275 http://dx.doi.org/10.3390/molecules19078916

Ejemplares similares

Antileishmanial Activity of a Series of N(2),N(4)-Disubstituted Quinazoline-2,4-diamines
por: Van Horn, Kurt S., et al.
Publicado: (2014)

Synthesis and evaluation of novel 2,4-disubstituted arylthiazoles against T. brucei
por: Georgiadis, Markos-Orestis, et al.
Publicado: (2019)

Novel 2,4-Disubstituted-1,3-Thiazole Derivatives: Synthesis, Anti-Candida Activity Evaluation and Interaction with Bovine Serum Albumine
por: Pricopie, Andreea-Iulia, et al.
Publicado: (2020)

1,4-Disubstituted Thiosemicarbazide Derivatives are Potent Inhibitors of Toxoplasma gondii Proliferation
por: Dzitko, Katarzyna, et al.
Publicado: (2014)

A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO(2)
por: Yu, Yan-Bo, et al.
Publicado: (2009)

Elucidation of Vasodilation Response and Structure Activity Relationships of N(2),N(4)-Disubstituted Quinazoline 2,4-Diamines in a Rat Pulmonary Artery Model
por: Paracha, Tamkeen Urooj, et al.
Publicado: (2019)

Discovery of Novel Quinazoline Derivatives as Potent Antitumor Agents
por: Niu, Zhenxi, et al.
Publicado: (2022)

Simple two-step synthesis of 2,4-disubstituted pyrroles and 3,5-disubstituted pyrrole-2-carbonitriles from enones
por: Kucukdisli, Murat, et al.
Publicado: (2014)

Quinazoline derivatives: synthesis and bioactivities
por: Wang, Dan, et al.
Publicado: (2013)

2,4-Dichloro-7-fluoroquinazoline
por: Gao, Feng, et al.
Publicado: (2012)

Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase
por: Mukherjee, Paramita, et al.
Publicado: (2014)

Synthesis and Antimalarial Activity of 1,4-Disubstituted Piperidine Derivatives
por: Seck, Rokhyatou, et al.
Publicado: (2020)

Evaluation of Synthetic 2,4-Disubstituted-benzo[g]quinoxaline Derivatives as Potential Anticancer Agents
por: Zaki, Islam, et al.
Publicado: (2021)

Synthesis, anti-varicella-zoster virus and anti-cytomegalovirus activity of quinazoline-2,4-diones containing isoxazolidine and phosphonate substructures
por: Piotrowska, Dorota G., et al.
Publicado: (2017)

Synthesis Biological Evaluation of Quinazoline-4-thiones
por: Kubicová, Lenka, et al.
Publicado: (2003)

Synthesis of 2,6-disubstituted tetrahydroazulene derivatives
por: Hussain, Zakir, et al.
Publicado: (2012)

Synthesis, Anti-microbial and Molecular Docking Studies of Quinazolin-4(3H)-one Derivatives
por: Mabkhot, Yahia Nasser, et al.
Publicado: (2014)

Optimisation of novel 4, 8-disubstituted dihydropyrimido[5,4-b][1,4]oxazine derivatives as potent GPR 119 agonists
por: Fang, Yuanying, et al.
Publicado: (2019)

Quinazolinone and quinazoline derivatives: recent structures with potent antimicrobial and cytotoxic activities
por: Jafari, Elham, et al.
Publicado: (2016)

2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19
por: Mallinger, Aurélie, et al.
Publicado: (2016)

2,4-Disubstituted pyridine derivatives are effective against intracellular and biofilm-forming tubercle bacilli
por: Korycka-Machała, M., et al.
Publicado: (2022)

Synthesis and anticancer activity of new quinazoline derivatives
por: Abuelizz, Hatem A., et al.
Publicado: (2017)

Cyclization of Chalcone Derivatives: Design, Synthesis, In Silico Docking Study, and Biological Evaluation of New Quinazolin-2,4-diones Incorporating Five-, Six-, and Seven-Membered Ring Moieties as Potent Antibacterial Inhibitors
por: El-Naggar, Mohamed, et al.
Publicado: (2023)

Quinazoline-2,4(1H,3H)-dione
por: Liu, Ge
Publicado: (2008)

Guanidine Derivatives of Quinazoline-2,4(1H,3H)-Dione as NHE-1 Inhibitors and Anti-Inflammatory Agents
por: Spasov, Alexander, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents
por: Romagnoli, Romeo, et al.
Publicado: (2017)

Synthesis, Computational Studies, Antioxidant and Anti-Inflammatory Bio-Evaluation of 2,5-Disubstituted-1,3,4-Oxadiazole Derivatives
por: Rana, Sibghat Mansoor, et al.
Publicado: (2023)

Synthesis and antileishmanial evaluation of some 2,3-disubstituted-4(3H)-quinazolinone derivatives
por: Birhan, Yihenew Simegniew, et al.
Publicado: (2014)

Synthesis and antimicrobial evaluation of some 2,5 disubstituted 1,3,4-oxadiazole derivatives
por: Jafari, Elham, et al.
Publicado: (2017)

Antimicrobial Activity of Quinazolin Derivatives of 1,2-Di(quinazolin-4-yl)diselane against Mycobacteria
por: Tang, Bikui, et al.
Publicado: (2017)

Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives
por: Georgey, Hanan, et al.
Publicado: (2008)

Discovery of Quinazoline-2,4(1H,3H)-Dione Derivatives as Potential Antibacterial Agent: Design, Synthesis, and Their Antibacterial Activity
por: Boshta, Nader M., et al.
Publicado: (2022)

Design, Synthesis, and Antitumor Activity of Novel Quinazoline Derivatives
por: Wang, Liuchang, et al.
Publicado: (2017)

Synthesis of chalcone incorporated quinazoline derivatives as anticancer agents
por: Madhavi, Sapavat, et al.
Publicado: (2017)

An Efficient One-Pot Catalyzed Synthesis of 2,4-Disubstituted 5-Nitroimidazoles Displaying Antiparasitic and Antibacterial Activities
por: Mathias, Fanny, et al.
Publicado: (2017)

Enantioselective Synthesis of 1,12‐Disubstituted [4]Helicenes
por: Hartung, Thierry, et al.
Publicado: (2020)

Synthesis of some new 2,3-disubstituted-4(3H)quinazolinone derivatives
por: Hassanzadeh, F., et al.
Publicado: (2012)

Discovery of novel quinazoline derivatives bearing semicarbazone moiety as potent EGFR kinase inhibitors
por: Tu, Yuanbiao, et al.
Publicado: (2018)

Computational modeling of novel quinazoline derivatives as potent epidermal growth factor receptor inhibitors
por: Ibrahim, Muhammad Tukur, et al.
Publicado: (2020)

Synthesis and bioactivities evaluation of quinazolin-4(3H)-one derivatives as α-glucosidase inhibitors
por: Moheb, Mahshid, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_km4sitq0p0mgcv4t4op2qsul0d