Synthetic Applications of Intramolecular Thiol-Ene “Click” Reactions

The intermolecular thiol-ene reaction is emerging as a highly efficient; free-radical mediated “click” process with diverse applications in biofunctionalisation and materials science. The related intramolecular thiol-ene reactions offer significant potential for the preparation of a wide range of su...

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Detalles Bibliográficos
Autores principales: Scanlan, Eoin M., Corcé, Vincent, Malone, Aoife
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271571/
https://www.ncbi.nlm.nih.gov/pubmed/25415476
http://dx.doi.org/10.3390/molecules191119137
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author Scanlan, Eoin M.
Corcé, Vincent
Malone, Aoife
author_facet Scanlan, Eoin M.
Corcé, Vincent
Malone, Aoife
author_sort Scanlan, Eoin M.
collection PubMed
description The intermolecular thiol-ene reaction is emerging as a highly efficient; free-radical mediated “click” process with diverse applications in biofunctionalisation and materials science. The related intramolecular thiol-ene reactions offer significant potential for the preparation of a wide range of sulphur containing heterocycles including synthetic therapeutics such as cyclic peptides and thiosugars. Herein, we review recent advances in intramolecular thiyl-radical mediated reactions and their applications for synthetic and medicinal chemistry.
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spelling pubmed-62715712019-01-07 Synthetic Applications of Intramolecular Thiol-Ene “Click” Reactions Scanlan, Eoin M. Corcé, Vincent Malone, Aoife Molecules Review The intermolecular thiol-ene reaction is emerging as a highly efficient; free-radical mediated “click” process with diverse applications in biofunctionalisation and materials science. The related intramolecular thiol-ene reactions offer significant potential for the preparation of a wide range of sulphur containing heterocycles including synthetic therapeutics such as cyclic peptides and thiosugars. Herein, we review recent advances in intramolecular thiyl-radical mediated reactions and their applications for synthetic and medicinal chemistry. MDPI 2014-11-19 /pmc/articles/PMC6271571/ /pubmed/25415476 http://dx.doi.org/10.3390/molecules191119137 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Scanlan, Eoin M.
Corcé, Vincent
Malone, Aoife
Synthetic Applications of Intramolecular Thiol-Ene “Click” Reactions
title Synthetic Applications of Intramolecular Thiol-Ene “Click” Reactions
title_full Synthetic Applications of Intramolecular Thiol-Ene “Click” Reactions
title_fullStr Synthetic Applications of Intramolecular Thiol-Ene “Click” Reactions
title_full_unstemmed Synthetic Applications of Intramolecular Thiol-Ene “Click” Reactions
title_short Synthetic Applications of Intramolecular Thiol-Ene “Click” Reactions
title_sort synthetic applications of intramolecular thiol-ene “click” reactions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271571/
https://www.ncbi.nlm.nih.gov/pubmed/25415476
http://dx.doi.org/10.3390/molecules191119137
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