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Berberine, an Epiphany Against Cancer

Alkaloids are used in traditional medicine for the treatment of many diseases. These compounds are synthesized in plants as secondary metabolites and have multiple effects on cellular metabolism. Among plant derivatives with biological properties, the isoquinoline quaternary alkaloid berberine posse...

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Autores principales: Guamán Ortiz, Luis Miguel, Lombardi, Paolo, Tillhon, Micol, Scovassi, Anna Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271598/
https://www.ncbi.nlm.nih.gov/pubmed/25153862
http://dx.doi.org/10.3390/molecules190812349
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author Guamán Ortiz, Luis Miguel
Lombardi, Paolo
Tillhon, Micol
Scovassi, Anna Ivana
author_facet Guamán Ortiz, Luis Miguel
Lombardi, Paolo
Tillhon, Micol
Scovassi, Anna Ivana
author_sort Guamán Ortiz, Luis Miguel
collection PubMed
description Alkaloids are used in traditional medicine for the treatment of many diseases. These compounds are synthesized in plants as secondary metabolites and have multiple effects on cellular metabolism. Among plant derivatives with biological properties, the isoquinoline quaternary alkaloid berberine possesses a broad range of therapeutic uses against several diseases. In recent years, berberine has been reported to inhibit cell proliferation and to be cytotoxic towards cancer cells. Based on this evidence, many derivatives have been synthesized to improve berberine efficiency and selectivity; the results so far obtained on human cancer cell lines support the idea that they could be promising agents for cancer treatment. The main properties of berberine and derivatives will be illustrated.
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spelling pubmed-62715982018-12-27 Berberine, an Epiphany Against Cancer Guamán Ortiz, Luis Miguel Lombardi, Paolo Tillhon, Micol Scovassi, Anna Ivana Molecules Review Alkaloids are used in traditional medicine for the treatment of many diseases. These compounds are synthesized in plants as secondary metabolites and have multiple effects on cellular metabolism. Among plant derivatives with biological properties, the isoquinoline quaternary alkaloid berberine possesses a broad range of therapeutic uses against several diseases. In recent years, berberine has been reported to inhibit cell proliferation and to be cytotoxic towards cancer cells. Based on this evidence, many derivatives have been synthesized to improve berberine efficiency and selectivity; the results so far obtained on human cancer cell lines support the idea that they could be promising agents for cancer treatment. The main properties of berberine and derivatives will be illustrated. MDPI 2014-08-15 /pmc/articles/PMC6271598/ /pubmed/25153862 http://dx.doi.org/10.3390/molecules190812349 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Guamán Ortiz, Luis Miguel
Lombardi, Paolo
Tillhon, Micol
Scovassi, Anna Ivana
Berberine, an Epiphany Against Cancer
title Berberine, an Epiphany Against Cancer
title_full Berberine, an Epiphany Against Cancer
title_fullStr Berberine, an Epiphany Against Cancer
title_full_unstemmed Berberine, an Epiphany Against Cancer
title_short Berberine, an Epiphany Against Cancer
title_sort berberine, an epiphany against cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271598/
https://www.ncbi.nlm.nih.gov/pubmed/25153862
http://dx.doi.org/10.3390/molecules190812349
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