Facile Synthesis of Bis(indolyl)methanes Catalyzed by α-Chymotrypsin

A mild and efficient method catalyzed by α-chymotrypsin was developed for the synthesis of bis(indolyl)methanes through a cascade process between indole and aromatic aldehydes. In the ethanol aqueous solution, a green medium, a wide range of aromatic aldehydes could react with indole to afford the d...

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Detalles Bibliográficos
Autores principales: Xie, Zong-Bo, Sun, Da-Zhao, Jiang, Guo-Fang, Le, Zhang-Gao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271608/
https://www.ncbi.nlm.nih.gov/pubmed/25438078
http://dx.doi.org/10.3390/molecules191219665
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author Xie, Zong-Bo
Sun, Da-Zhao
Jiang, Guo-Fang
Le, Zhang-Gao
author_facet Xie, Zong-Bo
Sun, Da-Zhao
Jiang, Guo-Fang
Le, Zhang-Gao
author_sort Xie, Zong-Bo
collection PubMed
description A mild and efficient method catalyzed by α-chymotrypsin was developed for the synthesis of bis(indolyl)methanes through a cascade process between indole and aromatic aldehydes. In the ethanol aqueous solution, a green medium, a wide range of aromatic aldehydes could react with indole to afford the desired products with moderate to good yields (from 68% to 95%) using a little α-chymotrypsin as catalyst.
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spelling pubmed-62716082018-12-28 Facile Synthesis of Bis(indolyl)methanes Catalyzed by α-Chymotrypsin Xie, Zong-Bo Sun, Da-Zhao Jiang, Guo-Fang Le, Zhang-Gao Molecules Article A mild and efficient method catalyzed by α-chymotrypsin was developed for the synthesis of bis(indolyl)methanes through a cascade process between indole and aromatic aldehydes. In the ethanol aqueous solution, a green medium, a wide range of aromatic aldehydes could react with indole to afford the desired products with moderate to good yields (from 68% to 95%) using a little α-chymotrypsin as catalyst. MDPI 2014-11-27 /pmc/articles/PMC6271608/ /pubmed/25438078 http://dx.doi.org/10.3390/molecules191219665 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xie, Zong-Bo
Sun, Da-Zhao
Jiang, Guo-Fang
Le, Zhang-Gao
Facile Synthesis of Bis(indolyl)methanes Catalyzed by α-Chymotrypsin
title Facile Synthesis of Bis(indolyl)methanes Catalyzed by α-Chymotrypsin
title_full Facile Synthesis of Bis(indolyl)methanes Catalyzed by α-Chymotrypsin
title_fullStr Facile Synthesis of Bis(indolyl)methanes Catalyzed by α-Chymotrypsin
title_full_unstemmed Facile Synthesis of Bis(indolyl)methanes Catalyzed by α-Chymotrypsin
title_short Facile Synthesis of Bis(indolyl)methanes Catalyzed by α-Chymotrypsin
title_sort facile synthesis of bis(indolyl)methanes catalyzed by α-chymotrypsin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271608/
https://www.ncbi.nlm.nih.gov/pubmed/25438078
http://dx.doi.org/10.3390/molecules191219665
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AT lezhanggao facilesynthesisofbisindolylmethanescatalyzedbyachymotrypsin

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