Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues

In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-quinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-alkylated propargyl-quinazoline and 1'-azido-2',3',5'-tri-O-benzoylribose or activated alkylat...

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Autores principales: Ouahrouch, Abdelaaziz, Taourirte, Moha, Engels, Joachim W., Benjelloun, Soumaya, Lazrek, Hassan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271638/
https://www.ncbi.nlm.nih.gov/pubmed/24662079
http://dx.doi.org/10.3390/molecules19033638
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author Ouahrouch, Abdelaaziz
Taourirte, Moha
Engels, Joachim W.
Benjelloun, Soumaya
Lazrek, Hassan B.
author_facet Ouahrouch, Abdelaaziz
Taourirte, Moha
Engels, Joachim W.
Benjelloun, Soumaya
Lazrek, Hassan B.
author_sort Ouahrouch, Abdelaaziz
collection PubMed
description In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-quinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-alkylated propargyl-quinazoline and 1'-azido-2',3',5'-tri-O-benzoylribose or activated alkylating agents under microwave conditions. None of the compounds selected showed significant anti-HCV activity in vitro.
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spelling pubmed-62716382018-12-20 Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues Ouahrouch, Abdelaaziz Taourirte, Moha Engels, Joachim W. Benjelloun, Soumaya Lazrek, Hassan B. Molecules Article In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-quinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-alkylated propargyl-quinazoline and 1'-azido-2',3',5'-tri-O-benzoylribose or activated alkylating agents under microwave conditions. None of the compounds selected showed significant anti-HCV activity in vitro. MDPI 2014-03-24 /pmc/articles/PMC6271638/ /pubmed/24662079 http://dx.doi.org/10.3390/molecules19033638 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Ouahrouch, Abdelaaziz
Taourirte, Moha
Engels, Joachim W.
Benjelloun, Soumaya
Lazrek, Hassan B.
Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues
title Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues
title_full Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues
title_fullStr Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues
title_full_unstemmed Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues
title_short Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues
title_sort synthesis of new 1,2,3-triazol-4-yl-quinazoline nucleoside and acyclonucleoside analogues
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271638/
https://www.ncbi.nlm.nih.gov/pubmed/24662079
http://dx.doi.org/10.3390/molecules19033638
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