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New Derivatives of 3,4-Dihydroisoquinoline-3-carboxylic Acid with Free-Radical Scavenging, d-Amino Acid Oxidase, Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activity

A series of 3,4-dihydroisoquinoline-3-carboxylic acid derivatives were synthesised and tested for their free-radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl radical (DPPH(·)), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS(·+)), superoxide anion radical (O(...

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Detalles Bibliográficos
Autores principales: Solecka, Jolanta, Guśpiel, Adam, Postek, Magdalena, Ziemska, Joanna, Kawęcki, Robert, Łęczycka, Katarzyna, Osior, Agnieszka, Pietrzak, Bartłomiej, Pypowski, Krzysztof, Wyrzykowska, Agata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271642/
https://www.ncbi.nlm.nih.gov/pubmed/25271427
http://dx.doi.org/10.3390/molecules191015866
Descripción
Sumario:A series of 3,4-dihydroisoquinoline-3-carboxylic acid derivatives were synthesised and tested for their free-radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl radical (DPPH(·)), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS(·+)), superoxide anion radical (O(2)(·−)) and nitric oxide radical ((·)NO) assays. We also studied d-amino acid oxidase (DAAO), acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activity. Almost each of newly synthesised compounds exhibited radical scavenging capabilities. Moreover, several compounds showed moderate inhibitory activities against DAAO, AChE and BuChE. Compounds with significant free-radical scavenging activity may be potential candidates for therapeutics used in oxidative-stress-related diseases.