New Derivatives of 3,4-Dihydroisoquinoline-3-carboxylic Acid with Free-Radical Scavenging, d-Amino Acid Oxidase, Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activity

A series of 3,4-dihydroisoquinoline-3-carboxylic acid derivatives were synthesised and tested for their free-radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl radical (DPPH(·)), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS(·+)), superoxide anion radical (O(...

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Autores principales: Solecka, Jolanta, Guśpiel, Adam, Postek, Magdalena, Ziemska, Joanna, Kawęcki, Robert, Łęczycka, Katarzyna, Osior, Agnieszka, Pietrzak, Bartłomiej, Pypowski, Krzysztof, Wyrzykowska, Agata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271642/
https://www.ncbi.nlm.nih.gov/pubmed/25271427
http://dx.doi.org/10.3390/molecules191015866
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author Solecka, Jolanta
Guśpiel, Adam
Postek, Magdalena
Ziemska, Joanna
Kawęcki, Robert
Łęczycka, Katarzyna
Osior, Agnieszka
Pietrzak, Bartłomiej
Pypowski, Krzysztof
Wyrzykowska, Agata
author_facet Solecka, Jolanta
Guśpiel, Adam
Postek, Magdalena
Ziemska, Joanna
Kawęcki, Robert
Łęczycka, Katarzyna
Osior, Agnieszka
Pietrzak, Bartłomiej
Pypowski, Krzysztof
Wyrzykowska, Agata
author_sort Solecka, Jolanta
collection PubMed
description A series of 3,4-dihydroisoquinoline-3-carboxylic acid derivatives were synthesised and tested for their free-radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl radical (DPPH(·)), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS(·+)), superoxide anion radical (O(2)(·−)) and nitric oxide radical ((·)NO) assays. We also studied d-amino acid oxidase (DAAO), acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activity. Almost each of newly synthesised compounds exhibited radical scavenging capabilities. Moreover, several compounds showed moderate inhibitory activities against DAAO, AChE and BuChE. Compounds with significant free-radical scavenging activity may be potential candidates for therapeutics used in oxidative-stress-related diseases.
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spelling pubmed-62716422018-12-27 New Derivatives of 3,4-Dihydroisoquinoline-3-carboxylic Acid with Free-Radical Scavenging, d-Amino Acid Oxidase, Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activity Solecka, Jolanta Guśpiel, Adam Postek, Magdalena Ziemska, Joanna Kawęcki, Robert Łęczycka, Katarzyna Osior, Agnieszka Pietrzak, Bartłomiej Pypowski, Krzysztof Wyrzykowska, Agata Molecules Article A series of 3,4-dihydroisoquinoline-3-carboxylic acid derivatives were synthesised and tested for their free-radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl radical (DPPH(·)), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS(·+)), superoxide anion radical (O(2)(·−)) and nitric oxide radical ((·)NO) assays. We also studied d-amino acid oxidase (DAAO), acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activity. Almost each of newly synthesised compounds exhibited radical scavenging capabilities. Moreover, several compounds showed moderate inhibitory activities against DAAO, AChE and BuChE. Compounds with significant free-radical scavenging activity may be potential candidates for therapeutics used in oxidative-stress-related diseases. MDPI 2014-09-30 /pmc/articles/PMC6271642/ /pubmed/25271427 http://dx.doi.org/10.3390/molecules191015866 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Solecka, Jolanta
Guśpiel, Adam
Postek, Magdalena
Ziemska, Joanna
Kawęcki, Robert
Łęczycka, Katarzyna
Osior, Agnieszka
Pietrzak, Bartłomiej
Pypowski, Krzysztof
Wyrzykowska, Agata
New Derivatives of 3,4-Dihydroisoquinoline-3-carboxylic Acid with Free-Radical Scavenging, d-Amino Acid Oxidase, Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activity
title New Derivatives of 3,4-Dihydroisoquinoline-3-carboxylic Acid with Free-Radical Scavenging, d-Amino Acid Oxidase, Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activity
title_full New Derivatives of 3,4-Dihydroisoquinoline-3-carboxylic Acid with Free-Radical Scavenging, d-Amino Acid Oxidase, Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activity
title_fullStr New Derivatives of 3,4-Dihydroisoquinoline-3-carboxylic Acid with Free-Radical Scavenging, d-Amino Acid Oxidase, Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activity
title_full_unstemmed New Derivatives of 3,4-Dihydroisoquinoline-3-carboxylic Acid with Free-Radical Scavenging, d-Amino Acid Oxidase, Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activity
title_short New Derivatives of 3,4-Dihydroisoquinoline-3-carboxylic Acid with Free-Radical Scavenging, d-Amino Acid Oxidase, Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activity
title_sort new derivatives of 3,4-dihydroisoquinoline-3-carboxylic acid with free-radical scavenging, d-amino acid oxidase, acetylcholinesterase and butyrylcholinesterase inhibitory activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271642/
https://www.ncbi.nlm.nih.gov/pubmed/25271427
http://dx.doi.org/10.3390/molecules191015866
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