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Antimicrobial Activity of Resveratrol Analogues
Stilbenes, especially resveratrol and its derivatives, have become famous for their positive effects on a wide range of medical disorders, as indicated by a huge number of published studies. A less investigated area of research is their antimicrobial properties. A series of 13 trans-resveratrol anal...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271662/ https://www.ncbi.nlm.nih.gov/pubmed/24918540 http://dx.doi.org/10.3390/molecules19067679 |
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author | Chalal, Malik Klinguer, Agnès Echairi, Abdelwahad Meunier, Philippe Vervandier-Fasseur, Dominique Adrian, Marielle |
author_facet | Chalal, Malik Klinguer, Agnès Echairi, Abdelwahad Meunier, Philippe Vervandier-Fasseur, Dominique Adrian, Marielle |
author_sort | Chalal, Malik |
collection | PubMed |
description | Stilbenes, especially resveratrol and its derivatives, have become famous for their positive effects on a wide range of medical disorders, as indicated by a huge number of published studies. A less investigated area of research is their antimicrobial properties. A series of 13 trans-resveratrol analogues was synthesized via Wittig or Heck reactions, and their antimicrobial activity assessed on two different grapevine pathogens responsible for severe diseases in the vineyard. The entire series, together with resveratrol, was first evaluated on the zoospore mobility and sporulation level of Plasmopara viticola (the oomycete responsible for downy mildew). Stilbenes displayed a spectrum of activity ranging from low to high. Six of them, including the most active ones, were subsequently tested on the development of Botrytis cinerea (fungus responsible for grey mold). The results obtained allowed us to identify the most active stilbenes against both grapevine pathogens, to compare the antimicrobial activity of the evaluated series of stilbenes, and to discuss the relationship between their chemical structure (number and position of methoxy and hydroxy groups) and antimicrobial activity. |
format | Online Article Text |
id | pubmed-6271662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62716622018-12-21 Antimicrobial Activity of Resveratrol Analogues Chalal, Malik Klinguer, Agnès Echairi, Abdelwahad Meunier, Philippe Vervandier-Fasseur, Dominique Adrian, Marielle Molecules Article Stilbenes, especially resveratrol and its derivatives, have become famous for their positive effects on a wide range of medical disorders, as indicated by a huge number of published studies. A less investigated area of research is their antimicrobial properties. A series of 13 trans-resveratrol analogues was synthesized via Wittig or Heck reactions, and their antimicrobial activity assessed on two different grapevine pathogens responsible for severe diseases in the vineyard. The entire series, together with resveratrol, was first evaluated on the zoospore mobility and sporulation level of Plasmopara viticola (the oomycete responsible for downy mildew). Stilbenes displayed a spectrum of activity ranging from low to high. Six of them, including the most active ones, were subsequently tested on the development of Botrytis cinerea (fungus responsible for grey mold). The results obtained allowed us to identify the most active stilbenes against both grapevine pathogens, to compare the antimicrobial activity of the evaluated series of stilbenes, and to discuss the relationship between their chemical structure (number and position of methoxy and hydroxy groups) and antimicrobial activity. MDPI 2014-06-10 /pmc/articles/PMC6271662/ /pubmed/24918540 http://dx.doi.org/10.3390/molecules19067679 Text en © 2014 by the authors. licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Chalal, Malik Klinguer, Agnès Echairi, Abdelwahad Meunier, Philippe Vervandier-Fasseur, Dominique Adrian, Marielle Antimicrobial Activity of Resveratrol Analogues |
title | Antimicrobial Activity of Resveratrol Analogues |
title_full | Antimicrobial Activity of Resveratrol Analogues |
title_fullStr | Antimicrobial Activity of Resveratrol Analogues |
title_full_unstemmed | Antimicrobial Activity of Resveratrol Analogues |
title_short | Antimicrobial Activity of Resveratrol Analogues |
title_sort | antimicrobial activity of resveratrol analogues |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271662/ https://www.ncbi.nlm.nih.gov/pubmed/24918540 http://dx.doi.org/10.3390/molecules19067679 |
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