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Antimicrobial Activity of Resveratrol Analogues

Stilbenes, especially resveratrol and its derivatives, have become famous for their positive effects on a wide range of medical disorders, as indicated by a huge number of published studies. A less investigated area of research is their antimicrobial properties. A series of 13 trans-resveratrol anal...

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Autores principales: Chalal, Malik, Klinguer, Agnès, Echairi, Abdelwahad, Meunier, Philippe, Vervandier-Fasseur, Dominique, Adrian, Marielle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271662/
https://www.ncbi.nlm.nih.gov/pubmed/24918540
http://dx.doi.org/10.3390/molecules19067679
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author Chalal, Malik
Klinguer, Agnès
Echairi, Abdelwahad
Meunier, Philippe
Vervandier-Fasseur, Dominique
Adrian, Marielle
author_facet Chalal, Malik
Klinguer, Agnès
Echairi, Abdelwahad
Meunier, Philippe
Vervandier-Fasseur, Dominique
Adrian, Marielle
author_sort Chalal, Malik
collection PubMed
description Stilbenes, especially resveratrol and its derivatives, have become famous for their positive effects on a wide range of medical disorders, as indicated by a huge number of published studies. A less investigated area of research is their antimicrobial properties. A series of 13 trans-resveratrol analogues was synthesized via Wittig or Heck reactions, and their antimicrobial activity assessed on two different grapevine pathogens responsible for severe diseases in the vineyard. The entire series, together with resveratrol, was first evaluated on the zoospore mobility and sporulation level of Plasmopara viticola (the oomycete responsible for downy mildew). Stilbenes displayed a spectrum of activity ranging from low to high. Six of them, including the most active ones, were subsequently tested on the development of Botrytis cinerea (fungus responsible for grey mold). The results obtained allowed us to identify the most active stilbenes against both grapevine pathogens, to compare the antimicrobial activity of the evaluated series of stilbenes, and to discuss the relationship between their chemical structure (number and position of methoxy and hydroxy groups) and antimicrobial activity.
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spelling pubmed-62716622018-12-21 Antimicrobial Activity of Resveratrol Analogues Chalal, Malik Klinguer, Agnès Echairi, Abdelwahad Meunier, Philippe Vervandier-Fasseur, Dominique Adrian, Marielle Molecules Article Stilbenes, especially resveratrol and its derivatives, have become famous for their positive effects on a wide range of medical disorders, as indicated by a huge number of published studies. A less investigated area of research is their antimicrobial properties. A series of 13 trans-resveratrol analogues was synthesized via Wittig or Heck reactions, and their antimicrobial activity assessed on two different grapevine pathogens responsible for severe diseases in the vineyard. The entire series, together with resveratrol, was first evaluated on the zoospore mobility and sporulation level of Plasmopara viticola (the oomycete responsible for downy mildew). Stilbenes displayed a spectrum of activity ranging from low to high. Six of them, including the most active ones, were subsequently tested on the development of Botrytis cinerea (fungus responsible for grey mold). The results obtained allowed us to identify the most active stilbenes against both grapevine pathogens, to compare the antimicrobial activity of the evaluated series of stilbenes, and to discuss the relationship between their chemical structure (number and position of methoxy and hydroxy groups) and antimicrobial activity. MDPI 2014-06-10 /pmc/articles/PMC6271662/ /pubmed/24918540 http://dx.doi.org/10.3390/molecules19067679 Text en © 2014 by the authors. licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chalal, Malik
Klinguer, Agnès
Echairi, Abdelwahad
Meunier, Philippe
Vervandier-Fasseur, Dominique
Adrian, Marielle
Antimicrobial Activity of Resveratrol Analogues
title Antimicrobial Activity of Resveratrol Analogues
title_full Antimicrobial Activity of Resveratrol Analogues
title_fullStr Antimicrobial Activity of Resveratrol Analogues
title_full_unstemmed Antimicrobial Activity of Resveratrol Analogues
title_short Antimicrobial Activity of Resveratrol Analogues
title_sort antimicrobial activity of resveratrol analogues
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271662/
https://www.ncbi.nlm.nih.gov/pubmed/24918540
http://dx.doi.org/10.3390/molecules19067679
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