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Anti-Inflammatory and Antipruritic Effects of Luteolin from Perilla (P. frutescens L.) Leaves

Perilla (Perilla frutescens L.) leaves have shown therapeutic efficacy in the treatment of inflammatory disorders, allergies, bronchial asthma, and systemic damage due to free radicals. In the present study we analyzed the active constituents in perilla leaves using high-performance liquid chromatog...

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Autores principales: Jeon, In Hwa, Kim, Hyeon Soo, Kang, Hyun Ju, Lee, Hyun-Seo, Jeong, Seung Il, Kim, Sang Jun, Jang, Seon Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271665/
https://www.ncbi.nlm.nih.gov/pubmed/24871572
http://dx.doi.org/10.3390/molecules19066941
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author Jeon, In Hwa
Kim, Hyeon Soo
Kang, Hyun Ju
Lee, Hyun-Seo
Jeong, Seung Il
Kim, Sang Jun
Jang, Seon Il
author_facet Jeon, In Hwa
Kim, Hyeon Soo
Kang, Hyun Ju
Lee, Hyun-Seo
Jeong, Seung Il
Kim, Sang Jun
Jang, Seon Il
author_sort Jeon, In Hwa
collection PubMed
description Perilla (Perilla frutescens L.) leaves have shown therapeutic efficacy in the treatment of inflammatory disorders, allergies, bronchial asthma, and systemic damage due to free radicals. In the present study we analyzed the active constituents in perilla leaves using high-performance liquid chromatography (HPLC) and isolated luteolin, a polyphenolic flavonoid. We investigated the anti-inflammatory and antipruritic properties of luteolin. Luteolin inhibited the secretion of inflammatory cytokines such as interleukin-1β (IL-1 β) and tumor necrosis factor-α (TNF-α) from human mast cells (HMC-1) stimulated with phorbol myristate acetate plus calcium ionophore A23187 in a dose-dependent manner. Luteolin also significantly reduced the histamine release from rat peritoneal mast cells stimulated by compound 48/80, a potent histamine liberator. Furthermore, the administration of luteolin markedly inhibited the scratching behavior and vascular permeability induced by pruritogens, such as compound 48/80 or serotonin, in ICR mice. These results suggested that luteolin has potential as a therapeutic agent against inflammation and itch-related skin diseases.
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spelling pubmed-62716652018-12-21 Anti-Inflammatory and Antipruritic Effects of Luteolin from Perilla (P. frutescens L.) Leaves Jeon, In Hwa Kim, Hyeon Soo Kang, Hyun Ju Lee, Hyun-Seo Jeong, Seung Il Kim, Sang Jun Jang, Seon Il Molecules Article Perilla (Perilla frutescens L.) leaves have shown therapeutic efficacy in the treatment of inflammatory disorders, allergies, bronchial asthma, and systemic damage due to free radicals. In the present study we analyzed the active constituents in perilla leaves using high-performance liquid chromatography (HPLC) and isolated luteolin, a polyphenolic flavonoid. We investigated the anti-inflammatory and antipruritic properties of luteolin. Luteolin inhibited the secretion of inflammatory cytokines such as interleukin-1β (IL-1 β) and tumor necrosis factor-α (TNF-α) from human mast cells (HMC-1) stimulated with phorbol myristate acetate plus calcium ionophore A23187 in a dose-dependent manner. Luteolin also significantly reduced the histamine release from rat peritoneal mast cells stimulated by compound 48/80, a potent histamine liberator. Furthermore, the administration of luteolin markedly inhibited the scratching behavior and vascular permeability induced by pruritogens, such as compound 48/80 or serotonin, in ICR mice. These results suggested that luteolin has potential as a therapeutic agent against inflammation and itch-related skin diseases. MDPI 2014-05-27 /pmc/articles/PMC6271665/ /pubmed/24871572 http://dx.doi.org/10.3390/molecules19066941 Text en © 2014 by the authors. licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Jeon, In Hwa
Kim, Hyeon Soo
Kang, Hyun Ju
Lee, Hyun-Seo
Jeong, Seung Il
Kim, Sang Jun
Jang, Seon Il
Anti-Inflammatory and Antipruritic Effects of Luteolin from Perilla (P. frutescens L.) Leaves
title Anti-Inflammatory and Antipruritic Effects of Luteolin from Perilla (P. frutescens L.) Leaves
title_full Anti-Inflammatory and Antipruritic Effects of Luteolin from Perilla (P. frutescens L.) Leaves
title_fullStr Anti-Inflammatory and Antipruritic Effects of Luteolin from Perilla (P. frutescens L.) Leaves
title_full_unstemmed Anti-Inflammatory and Antipruritic Effects of Luteolin from Perilla (P. frutescens L.) Leaves
title_short Anti-Inflammatory and Antipruritic Effects of Luteolin from Perilla (P. frutescens L.) Leaves
title_sort anti-inflammatory and antipruritic effects of luteolin from perilla (p. frutescens l.) leaves
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271665/
https://www.ncbi.nlm.nih.gov/pubmed/24871572
http://dx.doi.org/10.3390/molecules19066941
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