A New Cycloartane-Type Triterpenoid Saponin Xanthine Oxidase Inhibitor from Homonoia riparia Lour

A new cycloartane-type triterpenoid saponin named riparsaponin (1) was isolated from the stem of Homonoia riparia Lour together with six known compounds. The structure of riparsaponin was determined by using NMR and mass spectroscopy and X-ray crystallography techniques. Additionally, riparsaponin h...

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Detalles Bibliográficos
Autores principales: Xu, Fan, Zhao, Xueqian, Yang, Lingli, Wang, Xiuhua, Zhao, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271680/
https://www.ncbi.nlm.nih.gov/pubmed/25178063
http://dx.doi.org/10.3390/molecules190913422
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author Xu, Fan
Zhao, Xueqian
Yang, Lingli
Wang, Xiuhua
Zhao, Jing
author_facet Xu, Fan
Zhao, Xueqian
Yang, Lingli
Wang, Xiuhua
Zhao, Jing
author_sort Xu, Fan
collection PubMed
description A new cycloartane-type triterpenoid saponin named riparsaponin (1) was isolated from the stem of Homonoia riparia Lour together with six known compounds. The structure of riparsaponin was determined by using NMR and mass spectroscopy and X-ray crystallography techniques. Additionally, riparsaponin has a significant inhibitory effect on xanthine oxidase in vitro, and the IC(50) was 11.16 nmol/mL.
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spelling pubmed-62716802018-12-27 A New Cycloartane-Type Triterpenoid Saponin Xanthine Oxidase Inhibitor from Homonoia riparia Lour Xu, Fan Zhao, Xueqian Yang, Lingli Wang, Xiuhua Zhao, Jing Molecules Communication A new cycloartane-type triterpenoid saponin named riparsaponin (1) was isolated from the stem of Homonoia riparia Lour together with six known compounds. The structure of riparsaponin was determined by using NMR and mass spectroscopy and X-ray crystallography techniques. Additionally, riparsaponin has a significant inhibitory effect on xanthine oxidase in vitro, and the IC(50) was 11.16 nmol/mL. MDPI 2014-08-29 /pmc/articles/PMC6271680/ /pubmed/25178063 http://dx.doi.org/10.3390/molecules190913422 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Xu, Fan
Zhao, Xueqian
Yang, Lingli
Wang, Xiuhua
Zhao, Jing
A New Cycloartane-Type Triterpenoid Saponin Xanthine Oxidase Inhibitor from Homonoia riparia Lour
title A New Cycloartane-Type Triterpenoid Saponin Xanthine Oxidase Inhibitor from Homonoia riparia Lour
title_full A New Cycloartane-Type Triterpenoid Saponin Xanthine Oxidase Inhibitor from Homonoia riparia Lour
title_fullStr A New Cycloartane-Type Triterpenoid Saponin Xanthine Oxidase Inhibitor from Homonoia riparia Lour
title_full_unstemmed A New Cycloartane-Type Triterpenoid Saponin Xanthine Oxidase Inhibitor from Homonoia riparia Lour
title_short A New Cycloartane-Type Triterpenoid Saponin Xanthine Oxidase Inhibitor from Homonoia riparia Lour
title_sort new cycloartane-type triterpenoid saponin xanthine oxidase inhibitor from homonoia riparia lour
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271680/
https://www.ncbi.nlm.nih.gov/pubmed/25178063
http://dx.doi.org/10.3390/molecules190913422
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