Cargando…

Discovery of Novel c-Met Inhibitors Bearing a 3-Carboxyl Piperidin-2-one Scaffold

A series of compounds containing a novel 3-carboxypiperidin-2-one scaffold based on the lead structure BMS-777607 were designed, synthesized and evaluated for their c-Met kinase inhibition and cytotoxicity against MKN45 cancer cell lines. The results indicated that five compounds exhibited significa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Wei, Ai, Jing, Shi, Dakuo, Peng, Xia, Ji, Yinchun, Liu, Jian, Geng, Meiyu, Li, Yingxia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271681/ https://www.ncbi.nlm.nih.gov/pubmed/24566328 http://dx.doi.org/10.3390/molecules19022655

Ejemplares similares

Simm530, a novel and highly selective c-Met inhibitor, blocks c-Met-stimulated signaling and neoplastic activities
por: Wang, Ying, et al.
Publicado: (2016)

Phenyl piperidine-1-carboxylate
por: Shahwar, Durre, et al.
Publicado: (2009)

Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors
por: Fang, Feifei, et al.
Publicado: (2023)

Discovery of Potent c-MET Inhibitors with New Scaffold Having Different Quinazoline, Pyridine and Tetrahydro-Pyridothienopyrimidine Headgroups
por: Jiang, Yingnan, et al.
Publicado: (2016)

SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer
por: Zhou, Ji, et al.
Publicado: (2023)

Piperidine Azasugars Bearing Lipophilic Chains: Stereoselective Synthesis and Biological Activity as Inhibitors of Glucocerebrosidase (GCase)
por: Clemente, Francesca, et al.
Publicado: (2021)

tert-Butyl 1-hydroxypiperidine-2-carboxylate
por: Brücher, Oliver, et al.
Publicado: (2011)

Ethyl 3-methyl-2,6-diphenylpiperidine-1-carboxylate
por: Natarajan, Sampath, et al.
Publicado: (2011)

Tricyclohexyl(piperidine-1-dithiocarboxylato-κS)tin(IV)
por: Hao, Lujiang, et al.
Publicado: (2008)

Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids**
por: Rydzik, Anna M, et al.
Publicado: (2014)

Discovery of Triazolo-pyridazine/-pyrimidine Derivatives Bearing Aromatic (Heterocycle)-Coupled Azole Units as Class II c-Met Inhibitors
por: Zhang, Qian, et al.
Publicado: (2020)

tert-Butyl 4-(3,4-dichloroanilino)piperidine-1-carboxylate
por: Mehr-un-Nisa,, et al.
Publicado: (2013)

Synthesis and biological evaluation of novel quinoline-piperidine scaffolds as antiplasmodium agents
por: Van de Walle, Tim, et al.
Publicado: (2020)

1-(tert-Butoxycarbonyl)piperidine-4-carboxylic acid
por: Fun, Hoong-Kun, et al.
Publicado: (2011)

2,3,6-Triphenylpiperidin-4-one
por: Lavanya, N. Mahalakshmi, et al.
Publicado: (2009)

4-[4-(Piperidin-1-yl)piperidin-1-yl]benzonitrile
por: Xu, Guo-bin, et al.
Publicado: (2010)

An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars
por: Zhao, Hui, et al.
Publicado: (2013)

(S)-tert-Butyl 3-(3-phenyl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate
por: Liu, Lin, et al.
Publicado: (2010)

tert-Butyl 4-carbamoyl-3-methoxyimino-4-methylpiperidine-1-carboxylate
por: Wang, Juxian, et al.
Publicado: (2008)

Ethyl 4-[(E)-(2-hydroxybenzylidene)amino]piperidine-1-carboxylate
por: Fang, Rui-Qin, et al.
Publicado: (2011)

tert-Butyl 3-carbamoyl-4-methoxyimino-3-methylpiperidine-1-carboxylate
por: Chai, Yun, et al.
Publicado: (2009)

Chemical Modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazole-2-one Scaffold as a Novel NLRP3 Inhibitor
por: Gastaldi, Simone, et al.
Publicado: (2021)

One-Pot Route from Halogenated Amides to Piperidines and Pyrrolidines
por: Song, Qiao, et al.
Publicado: (2022)

Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure–activity relationship, crystal structural characterization and in vivo study
por: Wei, Peng, et al.
Publicado: (2019)

Preclinical evaluation of 3D185, a novel potent inhibitor of FGFR1/2/3 and CSF-1R, in FGFR-dependent and macrophage-dominant cancer models
por: Peng, Xia, et al.
Publicado: (2019)

Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors
por: Stokes, Ryjul W., et al.
Publicado: (2022)

tert-Butyl 4-(1-methyl-1H-pyrazol-5-yl)piperidine-1-carboxylate
por: Richter, Daniel, et al.
Publicado: (2009)

MET-targeting antibody (emibetuzumab) and kinase inhibitor (merestinib) as single agent or in combination in a cancer model bearing MET exon 14 skipping
por: Yan, S. Betty, et al.
Publicado: (2017)

1,3-Dimethyl-2,6-diphenylpiperidin-4-one
por: Nithya, P., et al.
Publicado: (2009)

(3E,5E)-3,5-Dibenzylidene-1-[3-(piperidin-1-yl)propanoyl]piperidin-4-one
por: Kia, Yalda, et al.
Publicado: (2011)

Design, synthesis and biological evaluation of 4-aminoquinoline derivatives as receptor-interacting protein kinase 2 (RIPK2) inhibitors
por: Fan, Tiantian, et al.
Publicado: (2022)

Poisonous Piperidine Plants and the Biodiversity of Norditerpenoid Alkaloids for Leads in Drug Discovery: Experimental Aspects
por: Qasem, Ashraf M. A., et al.
Publicado: (2022)

Discovery and computational studies of piperidine/piperazine-based compounds endowed with sigma receptor affinity
por: De Luca, Laura, et al.
Publicado: (2023)

Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor
por: Michaelides, Iacovos N., et al.
Publicado: (2023)

Discovery of Novel Biphenyl Carboxylic Acid Derivatives as Potent URAT1 Inhibitors
por: Hou, Xianxin, et al.
Publicado: (2023)

Leveraging the 1,3-azadiene-anhydride reaction for the synthesis of functionalized piperidines bearing up to five contiguous stereocenters
por: Garcia, Jorge, et al.
Publicado: (2021)

Piperidine-1-carboximidamide
por: Tiritiris, Ioannis
Publicado: (2012)

1-[(3-Nitrophenyl)(piperidin-1-yl)methyl]piperidine
por: Wang, Zhe-Qin, et al.
Publicado: (2012)

t-3-Pentyl-r-2,c-6-diphenylpiperidin-4-one
por: Gayathri, P., et al.
Publicado: (2009)

1,5-Bis(piperidin-1-yl)-9,10-anthraquinone
por: Niedziałkowski, Paweł, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_brd8gmu7vdm38tdfs3v8rt1dbq