Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B

Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger. The structures and relative stereochemistry of 1 and 2 were determined based on comparison with 3, and from extensive 1D and 2D NMR spe...

Descripción completa

Detalles Bibliográficos
Autores principales: Petersen, Lene M., Bladt, Tanja T., Dürr, Claudia, Seiffert, Martina, Frisvad, Jens C., Gotfredsen, Charlotte H., Larsen, Thomas O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271702/
https://www.ncbi.nlm.nih.gov/pubmed/25006786
http://dx.doi.org/10.3390/molecules19079786
_version_ 1783376988401041408
author Petersen, Lene M.
Bladt, Tanja T.
Dürr, Claudia
Seiffert, Martina
Frisvad, Jens C.
Gotfredsen, Charlotte H.
Larsen, Thomas O.
author_facet Petersen, Lene M.
Bladt, Tanja T.
Dürr, Claudia
Seiffert, Martina
Frisvad, Jens C.
Gotfredsen, Charlotte H.
Larsen, Thomas O.
author_sort Petersen, Lene M.
collection PubMed
description Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger. The structures and relative stereochemistry of 1 and 2 were determined based on comparison with 3, and from extensive 1D and 2D NMR spectroscopic analysis, supported by high resolution mass spectrometry (HRMS). Compounds 2 and 3 displayed cytotoxic activity towards chronic lymphocytic leukemia cells in vitro, with 3 being the most active.
format Online
Article
Text
id pubmed-6271702
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62717022018-12-21 Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B Petersen, Lene M. Bladt, Tanja T. Dürr, Claudia Seiffert, Martina Frisvad, Jens C. Gotfredsen, Charlotte H. Larsen, Thomas O. Molecules Article Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger. The structures and relative stereochemistry of 1 and 2 were determined based on comparison with 3, and from extensive 1D and 2D NMR spectroscopic analysis, supported by high resolution mass spectrometry (HRMS). Compounds 2 and 3 displayed cytotoxic activity towards chronic lymphocytic leukemia cells in vitro, with 3 being the most active. MDPI 2014-07-08 /pmc/articles/PMC6271702/ /pubmed/25006786 http://dx.doi.org/10.3390/molecules19079786 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Petersen, Lene M.
Bladt, Tanja T.
Dürr, Claudia
Seiffert, Martina
Frisvad, Jens C.
Gotfredsen, Charlotte H.
Larsen, Thomas O.
Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B
title Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B
title_full Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B
title_fullStr Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B
title_full_unstemmed Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B
title_short Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B
title_sort isolation, structural analyses and biological activity assays against chronic lymphocytic leukemia of two novel cytochalasins — sclerotionigrin a and b
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271702/
https://www.ncbi.nlm.nih.gov/pubmed/25006786
http://dx.doi.org/10.3390/molecules19079786
work_keys_str_mv AT petersenlenem isolationstructuralanalysesandbiologicalactivityassaysagainstchroniclymphocyticleukemiaoftwonovelcytochalasinssclerotionigrinaandb
AT bladttanjat isolationstructuralanalysesandbiologicalactivityassaysagainstchroniclymphocyticleukemiaoftwonovelcytochalasinssclerotionigrinaandb
AT durrclaudia isolationstructuralanalysesandbiologicalactivityassaysagainstchroniclymphocyticleukemiaoftwonovelcytochalasinssclerotionigrinaandb
AT seiffertmartina isolationstructuralanalysesandbiologicalactivityassaysagainstchroniclymphocyticleukemiaoftwonovelcytochalasinssclerotionigrinaandb
AT frisvadjensc isolationstructuralanalysesandbiologicalactivityassaysagainstchroniclymphocyticleukemiaoftwonovelcytochalasinssclerotionigrinaandb
AT gotfredsencharlotteh isolationstructuralanalysesandbiologicalactivityassaysagainstchroniclymphocyticleukemiaoftwonovelcytochalasinssclerotionigrinaandb
AT larsenthomaso isolationstructuralanalysesandbiologicalactivityassaysagainstchroniclymphocyticleukemiaoftwonovelcytochalasinssclerotionigrinaandb

Ejemplares similares