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Synthesis and Biological Evaluation of Novel Urea- and Guanidine-Based Derivatives for the Treatment of Obesity-Related Hepatic Steatosis

Leptin, the product of the obese gene, is an adipocyte-secreted protein hormone playing a key role in the progression of obesity and hepatic steatosis. In this study, 28 novel (thio)urea and guanidine-based analogues have been synthesized and N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-3...

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Detalles Bibliográficos
Autores principales:	Liang, Xiaolin, Pei, Heying, Ma, Liang, Ran, Yan, Chen, Jinying, Wang, Guangcheng, Chen, Lijuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271706/ https://www.ncbi.nlm.nih.gov/pubmed/24838072 http://dx.doi.org/10.3390/molecules19056163

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