A New Prenylated Indole Diketopiperazine Alkaloid from Eurotium cristatum

A new prenylated indole diketopiperazine alkaloid, cristatumin F (1), and four known metabolites, echinulin (2), dehydroechinulin (3), neoechinulin A (4) and variecolorin O (5), were isolated from the crude extract of the fungus Eurotium cristatum. The structure of 1 was elucidated primarily by NMR...

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Detalles Bibliográficos
Autores principales: Zou, Xianwei, Li, Ying, Zhang, Xiaona, Li, Qian, Liu, Xuan, Huang, Yun, Tang, Tao, Zheng, Saijing, Wang, Weimiao, Tang, Jintian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271712/
https://www.ncbi.nlm.nih.gov/pubmed/25372398
http://dx.doi.org/10.3390/molecules191117839
Descripción
Sumario:A new prenylated indole diketopiperazine alkaloid, cristatumin F (1), and four known metabolites, echinulin (2), dehydroechinulin (3), neoechinulin A (4) and variecolorin O (5), were isolated from the crude extract of the fungus Eurotium cristatum. The structure of 1 was elucidated primarily by NMR and MS methods. The absolute configuration of 1 was assigned using Marfey’s method applied to its acid hydrolyzate. Cristatumin F (1) showed modest radical scavenging activity against DPPH radicals, and exhibited marginal attenuation of 3T3L1 pre-adipocytes.

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