A New Prenylated Indole Diketopiperazine Alkaloid from Eurotium cristatum

A new prenylated indole diketopiperazine alkaloid, cristatumin F (1), and four known metabolites, echinulin (2), dehydroechinulin (3), neoechinulin A (4) and variecolorin O (5), were isolated from the crude extract of the fungus Eurotium cristatum. The structure of 1 was elucidated primarily by NMR...

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Autores principales: Zou, Xianwei, Li, Ying, Zhang, Xiaona, Li, Qian, Liu, Xuan, Huang, Yun, Tang, Tao, Zheng, Saijing, Wang, Weimiao, Tang, Jintian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271712/
https://www.ncbi.nlm.nih.gov/pubmed/25372398
http://dx.doi.org/10.3390/molecules191117839
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author Zou, Xianwei
Li, Ying
Zhang, Xiaona
Li, Qian
Liu, Xuan
Huang, Yun
Tang, Tao
Zheng, Saijing
Wang, Weimiao
Tang, Jintian
author_facet Zou, Xianwei
Li, Ying
Zhang, Xiaona
Li, Qian
Liu, Xuan
Huang, Yun
Tang, Tao
Zheng, Saijing
Wang, Weimiao
Tang, Jintian
author_sort Zou, Xianwei
collection PubMed
description A new prenylated indole diketopiperazine alkaloid, cristatumin F (1), and four known metabolites, echinulin (2), dehydroechinulin (3), neoechinulin A (4) and variecolorin O (5), were isolated from the crude extract of the fungus Eurotium cristatum. The structure of 1 was elucidated primarily by NMR and MS methods. The absolute configuration of 1 was assigned using Marfey’s method applied to its acid hydrolyzate. Cristatumin F (1) showed modest radical scavenging activity against DPPH radicals, and exhibited marginal attenuation of 3T3L1 pre-adipocytes.
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spelling pubmed-62717122019-01-07 A New Prenylated Indole Diketopiperazine Alkaloid from Eurotium cristatum Zou, Xianwei Li, Ying Zhang, Xiaona Li, Qian Liu, Xuan Huang, Yun Tang, Tao Zheng, Saijing Wang, Weimiao Tang, Jintian Molecules Article A new prenylated indole diketopiperazine alkaloid, cristatumin F (1), and four known metabolites, echinulin (2), dehydroechinulin (3), neoechinulin A (4) and variecolorin O (5), were isolated from the crude extract of the fungus Eurotium cristatum. The structure of 1 was elucidated primarily by NMR and MS methods. The absolute configuration of 1 was assigned using Marfey’s method applied to its acid hydrolyzate. Cristatumin F (1) showed modest radical scavenging activity against DPPH radicals, and exhibited marginal attenuation of 3T3L1 pre-adipocytes. MDPI 2014-11-03 /pmc/articles/PMC6271712/ /pubmed/25372398 http://dx.doi.org/10.3390/molecules191117839 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zou, Xianwei
Li, Ying
Zhang, Xiaona
Li, Qian
Liu, Xuan
Huang, Yun
Tang, Tao
Zheng, Saijing
Wang, Weimiao
Tang, Jintian
A New Prenylated Indole Diketopiperazine Alkaloid from Eurotium cristatum
title A New Prenylated Indole Diketopiperazine Alkaloid from Eurotium cristatum
title_full A New Prenylated Indole Diketopiperazine Alkaloid from Eurotium cristatum
title_fullStr A New Prenylated Indole Diketopiperazine Alkaloid from Eurotium cristatum
title_full_unstemmed A New Prenylated Indole Diketopiperazine Alkaloid from Eurotium cristatum
title_short A New Prenylated Indole Diketopiperazine Alkaloid from Eurotium cristatum
title_sort new prenylated indole diketopiperazine alkaloid from eurotium cristatum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271712/
https://www.ncbi.nlm.nih.gov/pubmed/25372398
http://dx.doi.org/10.3390/molecules191117839
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