2-(1H-Benzimidazol-2-yl)-4,5,6,7-tetrahydro-2H-indazol-3-ol, a Benzimidazole Derivative, Inhibits T Cell Proliferation Involving H+/K+-ATPase Inhibition

In this study, a benzimidazole derivative named BMT-1 is revealed as a potential immunomodulatory agent. BMT-1 inhibits the activity of H+/K+-ATPases from anti-CD3/CD28 activated T cells. Furthermore, inhibition the H+/K+-ATPases by use of BMT-1 should lead to intracellular acidification, inhibiting...

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Detalles Bibliográficos
Autores principales: Liu, Jin, Huang, Ning, Li, Ning, Liu, Si-Nian, Li, Min-Hui, Li, Hua, Luo, Xing-Yan, Wang, Yan-Tang, Li, Li-Mei, Zou, Qiang, Liu, Yang, Yang, Tai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271770/
https://www.ncbi.nlm.nih.gov/pubmed/25347460
http://dx.doi.org/10.3390/molecules191117173

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