Cargando…

Fused-Ring Derivatives of Quinoxalines: Spectroscopic Characterization and Photoinduced Processes Investigated by EPR Spin Trapping Technique

10-Ethyl-7-oxo-7,10-dihydropyrido[2,3-f]quinoxaline derivatives, synthesized as promising biologically/photobiologically active compounds were characterized by UV/vis, FT-IR and fluorescent spectroscopy. Photoinduced processes of these derivatives were studied by EPR spectroscopy, monitoring in situ...

Descripción completa

Detalles Bibliográficos
Autores principales: Barbieriková, Zuzana, Dvoranová, Dana, Bella, Maroš, Milata, Viktor, Czímerová, Adriana, Brezová, Vlasta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271815/
https://www.ncbi.nlm.nih.gov/pubmed/25120058
http://dx.doi.org/10.3390/molecules190812078
_version_ 1783377014434037760
author Barbieriková, Zuzana
Dvoranová, Dana
Bella, Maroš
Milata, Viktor
Czímerová, Adriana
Brezová, Vlasta
author_facet Barbieriková, Zuzana
Dvoranová, Dana
Bella, Maroš
Milata, Viktor
Czímerová, Adriana
Brezová, Vlasta
author_sort Barbieriková, Zuzana
collection PubMed
description 10-Ethyl-7-oxo-7,10-dihydropyrido[2,3-f]quinoxaline derivatives, synthesized as promising biologically/photobiologically active compounds were characterized by UV/vis, FT-IR and fluorescent spectroscopy. Photoinduced processes of these derivatives were studied by EPR spectroscopy, monitoring in situ the generation of reactive intermediates upon UVA (λ(max) = 365 nm) irradiation. The formation of reactive oxygen species and further oxygen- and carbon-centered radical intermediates was detected and possible reaction routes were suggested. To quantify the investigated processes, the quantum yields of the superoxide radical anion spin-adduct and 4-oxo-2,2,6,6-tetramethylpiperidine N-oxyl generation were determined, reflecting the activation of molecular oxygen by the excited state of the quinoxaline derivative.
format Online
Article
Text
id pubmed-6271815
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62718152018-12-27 Fused-Ring Derivatives of Quinoxalines: Spectroscopic Characterization and Photoinduced Processes Investigated by EPR Spin Trapping Technique Barbieriková, Zuzana Dvoranová, Dana Bella, Maroš Milata, Viktor Czímerová, Adriana Brezová, Vlasta Molecules Article 10-Ethyl-7-oxo-7,10-dihydropyrido[2,3-f]quinoxaline derivatives, synthesized as promising biologically/photobiologically active compounds were characterized by UV/vis, FT-IR and fluorescent spectroscopy. Photoinduced processes of these derivatives were studied by EPR spectroscopy, monitoring in situ the generation of reactive intermediates upon UVA (λ(max) = 365 nm) irradiation. The formation of reactive oxygen species and further oxygen- and carbon-centered radical intermediates was detected and possible reaction routes were suggested. To quantify the investigated processes, the quantum yields of the superoxide radical anion spin-adduct and 4-oxo-2,2,6,6-tetramethylpiperidine N-oxyl generation were determined, reflecting the activation of molecular oxygen by the excited state of the quinoxaline derivative. MDPI 2014-08-12 /pmc/articles/PMC6271815/ /pubmed/25120058 http://dx.doi.org/10.3390/molecules190812078 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Barbieriková, Zuzana
Dvoranová, Dana
Bella, Maroš
Milata, Viktor
Czímerová, Adriana
Brezová, Vlasta
Fused-Ring Derivatives of Quinoxalines: Spectroscopic Characterization and Photoinduced Processes Investigated by EPR Spin Trapping Technique
title Fused-Ring Derivatives of Quinoxalines: Spectroscopic Characterization and Photoinduced Processes Investigated by EPR Spin Trapping Technique
title_full Fused-Ring Derivatives of Quinoxalines: Spectroscopic Characterization and Photoinduced Processes Investigated by EPR Spin Trapping Technique
title_fullStr Fused-Ring Derivatives of Quinoxalines: Spectroscopic Characterization and Photoinduced Processes Investigated by EPR Spin Trapping Technique
title_full_unstemmed Fused-Ring Derivatives of Quinoxalines: Spectroscopic Characterization and Photoinduced Processes Investigated by EPR Spin Trapping Technique
title_short Fused-Ring Derivatives of Quinoxalines: Spectroscopic Characterization and Photoinduced Processes Investigated by EPR Spin Trapping Technique
title_sort fused-ring derivatives of quinoxalines: spectroscopic characterization and photoinduced processes investigated by epr spin trapping technique
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271815/
https://www.ncbi.nlm.nih.gov/pubmed/25120058
http://dx.doi.org/10.3390/molecules190812078
work_keys_str_mv AT barbierikovazuzana fusedringderivativesofquinoxalinesspectroscopiccharacterizationandphotoinducedprocessesinvestigatedbyeprspintrappingtechnique
AT dvoranovadana fusedringderivativesofquinoxalinesspectroscopiccharacterizationandphotoinducedprocessesinvestigatedbyeprspintrappingtechnique
AT bellamaros fusedringderivativesofquinoxalinesspectroscopiccharacterizationandphotoinducedprocessesinvestigatedbyeprspintrappingtechnique
AT milataviktor fusedringderivativesofquinoxalinesspectroscopiccharacterizationandphotoinducedprocessesinvestigatedbyeprspintrappingtechnique
AT czimerovaadriana fusedringderivativesofquinoxalinesspectroscopiccharacterizationandphotoinducedprocessesinvestigatedbyeprspintrappingtechnique
AT brezovavlasta fusedringderivativesofquinoxalinesspectroscopiccharacterizationandphotoinducedprocessesinvestigatedbyeprspintrappingtechnique